STX17 dynamically regulated by Fis1 induces mitophagy via hierarchical macroautophagic mechanism

• Published in: Nature communications Vol. 10; no. 1; pp. 2059 - 17
• Main Authors: Xian, Hongxu, Yang, Qiaoyun, Xiao, Lin, Shen, Han-Ming, Liou, Yih-Cherng
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 03.05.2019; Nature Publishing Group; Nature Portfolio
• Subjects: 13; 13/106; 13/109; 13/31; 13/89; 14; 14/19; 14/28; 14/34; 14/35; 631/80/313/2104; 631/80/39/2348; 631/80/642/333; Autophagy; Depletion; Electron transport; Endoplasmic Reticulum - metabolism; Gene Knockout Techniques; HEK293 Cells; HeLa Cells; Homeostasis; Humanities and Social Sciences; Humans; Membrane proteins; Membrane Proteins - genetics; Membrane Proteins - metabolism; Membranes; Mitochondria; Mitochondria - metabolism; Mitochondrial Proteins - genetics; Mitochondrial Proteins - metabolism; Mitophagy; multidisciplinary; Oligomerization; Parkin protein; Phagocytosis; Proteins; Proteomics; PTEN-induced putative kinase; Qa-SNARE Proteins - metabolism; Quality control; Science; SNAP receptors; Syntaxin

Mitophagy is the selective autophagic targeting and removal of dysfunctional mitochondria. While PINK1/Parkin-dependent mitophagy is well-characterized, PINK1/Parkin-independent route is poorly understood. Using structure illumination microscopy (SR-SIM), we demonstrate that the SNARE protein Syntax...