Combination therapy protects macaques against advanced Marburg virus disease

• Published in: Nature communications Vol. 12; no. 1; pp. 1891 - 10
• Main Authors: Cross, Robert W., Bornholdt, Zachary A., Prasad, Abhishek N., Borisevich, Viktoriya, Agans, Krystle N., Deer, Daniel J., Abelson, Dafna M., Kim, Do H., Shestowsky, William S., Campbell, Lioudmila A., Bunyan, Elaine, Geisbert, Joan B., Fenton, Karla A., Zeitlin, Larry, Porter, Danielle P., Geisbert, Thomas W.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 25.03.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 692/308/2778; 692/699/255/2514; Adenosine Monophosphate - analogs & derivatives; Adenosine Monophosphate - therapeutic use; Alanine - analogs & derivatives; Alanine - therapeutic use; Animals; Antibodies, Monoclonal - therapeutic use; Antibodies, Viral - therapeutic use; Antiviral drugs; Combination therapy; Disease Models, Animal; Drug Therapy, Combination; Filoviridae; Humanities and Social Sciences; Infectious diseases; Inoculation; Macaca mulatta; Marburg disease; Marburg Virus Disease - drug therapy; Marburg Virus Disease - prevention & control; Marburgvirus; Marburgvirus - drug effects; Monoclonal antibodies; multidisciplinary; Primates; Science; Science (multidisciplinary); Severe acute respiratory syndrome coronavirus 2; Therapy; Viral diseases; Viral infections; Viral Load - drug effects; Viruses

Monoclonal antibodies (mAbs) and remdesivir, a small-molecule antiviral, are promising monotherapies for many viruses, including members of the genera Marburgvirus and Ebolavirus (family Filoviridae ), and more recently, SARS-CoV-2. One of the major challenges of acute viral infections is the treatm...