APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer’s disease patient iPSC-derived cerebral organoids - Zhao, Jing; Fu, Yuan; Yamazaki, Yu; Ren, Yingxue; Davis, Mary D.; Liu, Chia-Chen; Lu, Wenyan; Wang, Xue; Chen, Kai; Cherukuri, Yesesri; Jia, Lin; Martens, Yuka A.; et al. (Nature communications, 2020)
Keywords: 13/100; 13/106; 631/378/1689/1283; 631/80/304; Alzheimer Disease - genetics; Alzheimer Disease - metabolism; Alzheimer's disease; Apolipoprotein E; Apolipoprotein E3 - genetics; Apolipoprotein E3 - metabolism; Apolipoprotein E4; Apolipoprotein E4 - genetics; Apoptosis; Cognition; Conversion; Dementia disorders; Gene Expression Regulation; Gene sequencing; Genotype; Genotypes; Humanities and Social Sciences; Humans; Induced Pluripotent Stem Cells - metabolism; Inhibitory postsynaptic potentials; multidisciplinary; Neurodegeneration; Neurodegenerative diseases; Organoids; Organoids - metabolism; Organoids - pathology; Pathogenesis; Patients; Phenotypes; Pluripotency; Ribonucleic acid; Risk analysis; Risk factors; RNA; RNA - metabolism; Science; Science (multidisciplinary); Stem cells; Synapses; Synapses - metabolism; Tau protein; Transcriptome; Transcriptomics