Defining early changes in Alzheimer’s disease from RNA sequencing of brain regions differentially affected by pathology

• Published in: Scientific reports Vol. 11; no. 1; pp. 4865 - 15
• Main Authors: Guennewig, Boris, Lim, Julia, Marshall, Lee, McCorkindale, Andrew N., Paasila, Patrick J., Patrick, Ellis, Kril, Jillian J., Halliday, Glenda M., Cooper, Antony A., Sutherland, Greg T.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.03.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 631/378/1689/1283; 692/617/375/132/1283; Aged; Aged, 80 and over; Alzheimer Disease - genetics; Alzheimer Disease - metabolism; Alzheimer Disease - pathology; Alzheimer's disease; Autopsy; Cortex (parietal); Female; Gene expression; Humanities and Social Sciences; Humans; Insulin; Insulin-like growth factor I; Male; Middle Aged; multidisciplinary; Myeloid cells; Neurodegenerative diseases; Neurotransmission; Pathology; Primary Visual Cortex - metabolism; Primary Visual Cortex - pathology; Ribonucleic acid; RNA; RNA-Seq; Science; Science (multidisciplinary); Somatostatin; Tau protein; Temporal lobe; Transcriptome; Transcriptomes; Transcriptomics; Visual cortex

Tau pathology in Alzheimer’s disease (AD) spreads in a predictable pattern that corresponds with disease symptoms and severity. At post-mortem there are cortical regions that range from mildly to severely affected by tau pathology and neuronal loss. A comparison of the molecular signatures of these...