SREBP-dependent lipidomic reprogramming as a broad-spectrum antiviral target - Yuan, Shuofeng; Chu, Hin; Chan, Jasper Fuk-Woo; Ye, Zi-Wei; Wen, Lei; Yan, Bingpeng; Lai, Pok-Man; Tee, Kah-Meng; Huang, Jingjing; Chen, Dongdong; Li, Cun; Zhao, Xiaoyu; et al. (Nature communications, 2019)
Keywords: 101/58; 14/19; 14/28; 49/31; 49/91; 49/98; 631/154/555; 631/326/596/1296; 631/45/608; 64/110; 692/699/255/2514; 96/1; Antiviral activity; Antiviral Agents - pharmacology; Antiviral drugs; Benzoates - chemistry; Benzoates - metabolism; Benzoates - pharmacology; Biosynthesis; Biosynthetic Pathways - drug effects; Chemical synthesis; Coronaviridae; Coronaviruses; Humanities and Social Sciences; Influenza A; Influenza A virus - drug effects; Influenza A virus - physiology; Life cycle engineering; Life cycles; Lipid Metabolism - drug effects; Lipids; Lipids - biosynthesis; Membrane proteins; Membrane vesicles; Middle East Respiratory Syndrome Coronavirus - drug effects; Middle East Respiratory Syndrome Coronavirus - physiology; multidisciplinary; Organic chemistry; Palmitoylation; Protein Binding; Proteins; Proteolysis; Retinoids - chemistry; Retinoids - metabolism; Retinoids - pharmacology; Science; Science (multidisciplinary); Sterol Regulatory Element Binding Proteins - metabolism; Sterol regulatory element-binding protein; Tetrahydronaphthalenes - chemistry; Tetrahydronaphthalenes - metabolism; Tetrahydronaphthalenes - pharmacology; Therapeutic applications; Viral infections; Virus Diseases - prevention & control; Virus Diseases - virology; Virus Replication - drug effects; Viruses