ZCCHC3 is a co-sensor of cGAS for dsDNA recognition in innate immune response

• Published in: Nature communications Vol. 9; no. 1; pp. 3349 - 13
• Main Authors: Lian, Huan, Wei, Jin, Zang, Ru, Ye, Wen, Yang, Qing, Zhang, Xia-Nan, Chen, Yun-Da, Fu, Yu-Zhi, Hu, Ming-Ming, Lei, Cao-Qi, Luo, Wei-Wei, Li, Shu, Shu, Hong-Bing
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 22.08.2018; Nature Publishing Group; Nature Portfolio
• Subjects: 13/106; 13/109; 13/89; 14/19; 38/77; 42/109; 631/250/2499; 631/250/262; 631/326/596/2553; 692/420/254; 96; 96/1; 96/95; AMP; Animals; Binding; Chemical synthesis; Cyclic GMP; Cytosol; Deoxyribonucleic acid; DNA; DNA - genetics; DNA - metabolism; DNA viruses; Herpes simplex; Humanities and Social Sciences; Immune response; Immune system; Immunity, Innate - genetics; Immunity, Innate - physiology; Infections; Innate immunity; Mice; Mice, Knockout; multidisciplinary; Nucleotides, Cyclic - metabolism; Nucleotidyltransferases - genetics; Nucleotidyltransferases - metabolism; Proteins; Recognition; RNA Nucleotidyltransferases - genetics; RNA Nucleotidyltransferases - metabolism; Science; Signal Transduction - genetics; Signal Transduction - physiology; Viral infections; Viruses; Zinc; Zinc finger proteins

Cyclic GMP-AMP synthase (cGAS) senses double-strand (ds) DNA in the cytosol and then catalyzes synthesis of the second messenger cGAMP, which activates the adaptor MITA/STING to initiate innate antiviral response. How cGAS activity is regulated remains enigmatic. Here, we identify ZCCHC3, a CCHC-typ...