Metformin may induce ferroptosis by inhibiting autophagy via lncRNA H19 in breast cancer

• Published in: FEBS open bio Vol. 12; no. 1; pp. 146 - 153
• Main Authors: Chen, Jida, Qin, Chuan, Zhou, Yulu, Chen, Yongxia, Mao, Misha, Yang, Jingjing
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.01.2022; John Wiley and Sons Inc; Wiley
• Subjects: Apoptosis; Autophagy; Autophagy - genetics; biomedical research; Breast cancer; breast neoplasms; Breast Neoplasms - drug therapy; Breast Neoplasms - genetics; Cancer therapies; carcinogenesis; Cell culture; Female; Ferroptosis; Ferroptosis - genetics; H19; Humans; Lipids; Mammals; Medical research; Metformin; Metformin - pharmacology; Non-coding RNA; Protein expression; Proteins; Reactive oxygen species; RNA, Long Noncoding - genetics; Tumorigenesis; Tumors; United States > US; H19; breast cancer; metformin; autophagy; ferroptosis

Autophagy and ferroptosis have been major foci of biomedical research in recent years. Elucidation of their intrinsic molecular relationships is important for cancer prevention and treatment. Metformin can directly inhibit tumorigenesis, although the mechanism responsible for this is not fully under...