Exosomal HMGB1 derived from hypoxia‐conditioned bone marrow mesenchymal stem cells increases angiogenesis via the JNK/HIF‐1α pathway

• Published in: FEBS open bio Vol. 11; no. 5; pp. 1364 - 1373
• Main Authors: Gao, Wenling, He, Ronghan, Ren, Jianhua, Zhang, Wenhui, Wang, Kun, Zhu, Lei, Liang, Tangzhao
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.05.2021; John Wiley and Sons Inc; Wiley
• Subjects: Angiogenesis; Bone marrow; bone marrow mesenchymal stem cells; Cell growth; Cell Hypoxia - physiology; Cell migration; Cell Proliferation; Cell viability; Cytokines; Dehydrogenases; Endothelial cells; exosome; Exosomes; Exosomes - metabolism; Exosomes - physiology; fluorescent antibody technique; Gene expression; High mobility group proteins; HMGB1; HMGB1 protein; HMGB1 Protein - genetics; HMGB1 Protein - metabolism; Human Umbilical Vein Endothelial Cells - metabolism; Humans; Hypoxia; Hypoxia - metabolism; Hypoxia-Inducible Factor 1, alpha Subunit - genetics; Hypoxia-Inducible Factor 1, alpha Subunit - metabolism; Immunofluorescence; MAP Kinase Signaling System - genetics; Mesenchymal stem cells; Mesenchymal Stem Cells - metabolism; Mesenchymal Stem Cells - physiology; Neovascularization, Pathologic - genetics; Neovascularization, Pathologic - metabolism; Neovascularization, Physiologic; nucleoproteins; Paracrine signalling; Proteins; secretion; Signal transduction; Signal Transduction - physiology; Stains & staining; Standard deviation; Stem cells; Transmission electron microscopy; Umbilical vein; Vascular endothelial growth factor; Vascular Endothelial Growth Factor A - metabolism; Western blotting; United States > US; China; hypoxia; HMGB1; bone marrow mesenchymal stem cells; exosome; angiogenesis

Mesenchymal stem cells (MSCs) have been described to induce angiogenesis in various tissues and have been used for the development of novel cell‐based therapies. Increasing evidence suggests that MSCs execute their paracrine function via the secretion of exosomes, especially under hypoxic conditions...