A comprehensive overview and evaluation of circular RNA detection tools

• Published in: PLoS computational biology Vol. 13; no. 6; p. e1005420
• Main Authors: Zeng, Xiangxiang, Lin, Wei, Guo, Maozu, Zou, Quan
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.06.2017; Public Library of Science (PLoS)
• Subjects: Acids; Algorithms; Base Sequence; Binding sites; Bioindicators; Bioinformatics; Biology; Biology and life sciences; Biomarkers; Circular RNA; Circularity; Civil engineering; Colleges & universities; Computer and Information Sciences; Database Management Systems; Databases, Nucleic Acid; Engineering and Technology; Gene expression; Genomes; HeLa Cells; Humans; Identification; Information science; Methods; MicroRNA; MicroRNAs; Mimicry; miRNA; Physiological aspects; Pipelines; Polyadenylation; Regulators; Research and analysis methods; Review; Ribonucleic acid; RNA; RNA - chemistry; RNA - genetics; RNA polymerase; RNA sequencing; Sensitivity; Sensitivity analysis; Sequence Alignment; Sequence Analysis, RNA; Sponges; Transcription

Circular RNA (circRNA) is mainly generated by the splice donor of a downstream exon joining to an upstream splice acceptor, a phenomenon known as backsplicing. It has been reported that circRNA can function as microRNA (miRNA) sponges, transcriptional regulators, or potential biomarkers. The availab...