Impact of the Age of Cecal Material Transfer Donors on Alzheimer’s Disease Pathology in 5xFAD Mice

• Published in: Microorganisms Vol. 9; no. 12; p. 2548
• Main Authors: Valeri, Francesco, dos Santos Guilherme, Malena, He, Fuqian, Stoye, Nicolai M., Schwiertz, Andreas, Endres, Kristina
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 09.12.2021; MDPI
• Subjects: Age; Aging; aging; amyloid; antibiotics; dysbiosis; fecal material transplant; microbiome; Alzheimer's disease; amyloid; Animal models; Animals; Antibiotics; Behavior; Biology (General); blood serum; Cecum; Convulsions & seizures; Dentate gyrus; disease models; Drinking water; dysbiosis; Enterobacteriaceae; fecal material transplant; Feces; Guillain-Barre syndrome; Inoculation; Investigations; Lactobacillaceae; microbiome; Microbiomes; Multiple sclerosis; Neurodegenerative diseases; Pathogenesis; phenotype; Phenotypes; Prefrontal cortex; QH301-705.5; therapeutics; Transgenic animals; Germany; amyloid; aging; antibiotics; microbiome; dysbiosis; fecal material transplant

Alzheimer’s disease is a progressive neurodegenerative disorder affecting around 30 million patients worldwide. The predominant sporadic variant remains enigmatic as the underlying cause has still not been identified. Since efficient therapeutic treatments are still lacking, the microbiome and its m...