Induction of alpha-synuclein pathology in the enteric nervous system of the rat and non-human primate results in gastrointestinal dysmotility and transient CNS pathology

• Published in: Neurobiology of disease Vol. 112; pp. 106 - 118
• Main Authors: Manfredsson, Fredric P., Luk, Kelvin C., Benskey, Matthew J., Gezer, Aysegul, Garcia, Joanna, Kuhn, Nathan C., Sandoval, Ivette M., Patterson, Joseph R., O'Mara, Alana, Yonkers, Reid, Kordower, Jeffrey H.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2018; Elsevier
• Subjects: Alpha-synuclein; alpha-Synuclein - biosynthesis; Animals; Central Nervous System Diseases - metabolism; Central Nervous System Diseases - pathology; Enteric dysfunction; Enteric nervous system; Enteric Nervous System - metabolism; Enteric Nervous System - pathology; Gastrointestinal Diseases - metabolism; Gastrointestinal Diseases - pathology; Gastrointestinal Motility - physiology; Humans; Macaca fascicularis; Male; Mice; Parkinson's disease; Primates; Prion spread; Rats; Rats, Sprague-Dawley; Prion spread; Enteric nervous system; Parkinson's disease; Alpha-synuclein; Enteric dysfunction

Alpha-Synuclein (α-syn) is by far the most highly vetted pathogenic and therapeutic target in Parkinson's disease. Aggregated α-syn is present in sporadic Parkinson's disease, both in the central nervous system (CNS) and peripheral nervous system (PNS). The enteric division of the PNS is o...