TIGIT Marks Exhausted T Cells, Correlates with Disease Progression, and Serves as a Target for Immune Restoration in HIV and SIV Infection

• Published in: PLoS pathogens Vol. 12; no. 1; p. e1005349
• Main Authors: Chew, Glen M., Fujita, Tsuyoshi, Webb, Gabriela M., Burwitz, Benjamin J., Wu, Helen L., Reed, Jason S., Hammond, Katherine B., Clayton, Kiera L., Ishii, Naoto, Abdel-Mohsen, Mohamed, Liegler, Teri, Mitchell, Brooks I., Hecht, Frederick M., Ostrowski, Mario, Shikuma, Cecilia M., Hansen, Scott G., Maurer, Mark, Korman, Alan J., Deeks, Steven G., Sacha, Jonah B., Ndhlovu, Lishomwa C.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.01.2016; Public Library of Science (PLoS)
• Subjects: Acquired immune deficiency syndrome; AIDS; Animals; B7-H1 Antigen - immunology; CD4-Positive T-Lymphocytes - immunology; CD8-Positive T-Lymphocytes - immunology; Cell Separation; Development and progression; Disease; Disease Progression; DNA, Viral - analysis; Flow Cytometry; Funding; Health aspects; HIV; HIV infection; HIV Infections - immunology; Host-virus relationships; Human immunodeficiency virus; Humans; Immune response; Infections; Lymphocyte Activation - immunology; Lymphocytes; Macaca mulatta; Mortality; Observations; Receptors, Immunologic - immunology; RNA, Viral - analysis; Simian Acquired Immunodeficiency Syndrome - immunology; Simian immunodeficiency virus; Statistical analysis; T cells; Viral infections

HIV infection induces phenotypic and functional changes to CD8+ T cells defined by the coordinated upregulation of a series of negative checkpoint receptors that eventually result in T cell exhaustion and failure to control viral replication. We report that effector CD8+ T cells during HIV infection...