Cell-Specific Cardiac Electrophysiology Models

• Published in: PLoS computational biology Vol. 11; no. 4; p. e1004242
• Main Authors: Groenendaal, Willemijn, Ortega, Francis A., Kherlopian, Armen R., Zygmunt, Andrew C., Krogh-Madsen, Trine, Christini, David J.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.04.2015; Public Library of Science (PLoS)
• Subjects: Action Potentials - physiology; Animals; Automation; Behavior; Cells, Cultured; Computer Simulation; Electrophysiology; Experiments; Heart cells; Heart Conduction System - physiology; Ion Channel Gating - physiology; Ion Channels - physiology; Mathematical models; Membrane Potentials - physiology; Models, Cardiovascular; Models, Statistical; Myocytes, Cardiac - physiology; Physiological aspects; Rodents; Swine

The traditional cardiac model-building paradigm involves constructing a composite model using data collected from many cells. Equations are derived for each relevant cellular component (e.g., ion channel, exchanger) independently. After the equations for all components are combined to form the compo...