BPDE induced lymphocytic chromosome 3p deletions may predict renal cell carcinoma risk

• Published in: The Journal of urology Vol. 179; no. 6; p. 2416
• Main Authors: Zhu, Yimin, Horikawa, Yohei, Yang, Hushan, Wood, Christopher G, Habuchi, Tomonori, Wu, Xifeng
• Format: Journal Article
• Language: English
• Published: United States 01.06.2008
• Subjects: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide - adverse effects; Carcinogens - pharmacology; Carcinoma, Renal Cell - chemically induced; Case-Control Studies; Cells, Cultured; Chromosome Deletion; Chromosomes, Human, Pair 3 - drug effects; Female; Humans; Kidney Neoplasms - chemically induced; Lymphocytes; Male; Middle Aged; Risk Factors

Cigarette smoking is a risk factor for renal cell carcinoma. BPDE (benzo[alpha]pyrene diol epoxide) (Midwest Research Institute, Kansas City, Missouri), which is a major constituent of cigarette smoke, induces 3p aberrations that are associated with susceptibility to other smoking associated cancers...