Laboratory evolution reveals a two-dimensional rate-yield tradeoff in microbial metabolism

• Published in: PLoS computational biology Vol. 15; no. 6; p. e1007066
• Main Authors: Cheng, Chuankai, O’Brien, Edward J., McCloskey, Douglas, Utrilla, Jose, Olson, Connor, LaCroix, Ryan A., Sandberg, Troy E., Feist, Adam M., Palsson, Bernhard O., King, Zachary A.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.06.2019; Public Library of Science (PLoS)
• Subjects: Adaptation; Amino acids; Bacterial Proteins - genetics; Bacterial Proteins - metabolism; Bioengineering; Biology and Life Sciences; Biomass; Carbon; Complexity; Computer applications; E coli; Enzymes; Escherichia coli; Escherichia coli - genetics; Escherichia coli - metabolism; Evolution; Evolution & development; Evolution (Biology); Evolution, Molecular; Experiments; Fermentation; Funding; Gene expression; Genes; Genome, Bacterial - genetics; Genomes; Genomics; Glucose; Glucose metabolism; Glycolysis; Growth rate; Laboratories; Mathematical models; Medicine and Health Sciences; Metabolism; Microbial growth; Microbial metabolism; Microorganisms; Models, Biological; Molecular weight; Monosaccharides; Multiscale analysis; Mutation; Natural history; Overflow; Pentose; Pentose phosphate pathway; Phosphates; Physical Sciences; Proteins; Proteome - genetics; Proteome - metabolism; Proteomes; Respiration; Scale models; Software; Substrates; Systems Biology; Tradeoffs; Two dimensional analysis; Two dimensional models; Yield; United States; Denmark; La Jolla California; California; United States > US

Growth rate and yield are fundamental features of microbial growth. However, we lack a mechanistic and quantitative understanding of the rate-yield relationship. Studies pairing computational predictions with experiments have shown the importance of maintenance energy and proteome allocation in expl...