Laboratory evolution reveals a two-dimensional rate-yield tradeoff in microbial metabolism - Cheng, Chuankai; O’Brien, Edward J.; McCloskey, Douglas; Utrilla, Jose; Olson, Connor; LaCroix, Ryan A.; Sandberg, Troy E.; Feist, Adam M.; Palsson, Bernhard O.; King, Zachary A. (PLoS computational biology, 2019)
Keywords: Adaptation; Amino acids; Bacterial Proteins - genetics; Bacterial Proteins - metabolism; Bioengineering; Biology and Life Sciences; Biomass; Carbon; Complexity; Computer applications; E coli; Enzymes; Escherichia coli; Escherichia coli - genetics; Escherichia coli - metabolism; Evolution; Evolution & development; Evolution (Biology); Evolution, Molecular; Experiments; Fermentation; Funding; Gene expression; Genes; Genome, Bacterial - genetics; Genomes; Genomics; Glucose; Glucose metabolism; Glycolysis; Growth rate; Laboratories; Mathematical models; Medicine and Health Sciences; Metabolism; Microbial growth; Microbial metabolism; Microorganisms; Models, Biological; Molecular weight; Monosaccharides; Multiscale analysis; Mutation; Natural history; Overflow; Pentose; Pentose phosphate pathway; Phosphates; Physical Sciences; Proteins; Proteome - genetics; Proteome - metabolism; Proteomes; Respiration; Scale models; Software; Substrates; Systems Biology; Tradeoffs; Two dimensional analysis; Two dimensional models; Yield; United States; Denmark; La Jolla California; California; United States--US