Hsp70 Isoforms Are Essential for the Formation of Kaposi's Sarcoma-Associated Herpesvirus Replication and Transcription Compartments

• Published in: PLoS pathogens Vol. 11; no. 11; p. e1005274
• Main Authors: Baquero-Pérez, Belinda, Whitehouse, Adrian
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.11.2015; Public Library of Science (PLoS)
• Subjects: Analysis; Cancer; Care and treatment; Cell cycle; Clinical trials; Colleges & universities; Complications and side effects; Cytoplasm; Cytotoxicity; Deoxyribonucleic acid; DNA; DNA replication; DNA Replication - genetics; Gene Expression Regulation, Viral - genetics; Genes; Genetic transcription; Genome, Viral - genetics; Herpesviridae Infections - complications; Herpesviridae Infections - genetics; Herpesviridae Infections - metabolism; Herpesvirus 8, Human - drug effects; Herpesvirus 8, Human - genetics; Herpesvirus 8, Human - physiology; HSP70 Heat-Shock Proteins - genetics; HSP70 Heat-Shock Proteins - metabolism; Humans; Influence; Kaposi's sarcoma; Kaposis sarcoma; Labeling; Medical research; Molecular chaperones; Molecular weight; Protein Isoforms - genetics; Protein Isoforms - metabolism; Proteomics; Purine Nucleosides - pharmacology; RNA polymerase; Sarcoma, Kaposi - virology; Transcription, Genetic; Viral infections; Viral Proteins - genetics; Viral Proteins - metabolism; Virion - genetics; Virus Replication - drug effects; Viruses

Kaposi's sarcoma-associated herpesvirus (KSHV) is an oncogenic herpesvirus associated with various AIDS-related malignancies. Like other herpesviruses, multiple processes required for KSHV lytic replication, including viral transcription, viral DNA synthesis and capsid assembly occur in virus-i...