RNF26 temporally regulates virus-triggered type I interferon induction by two distinct mechanisms

• Published in: PLoS pathogens Vol. 10; no. 9; p. e1004358
• Main Authors: Qin, Yue, Zhou, Mao-Tian, Hu, Ming-Ming, Hu, Yun-Hong, Zhang, Jing, Guo, Lin, Zhong, Bo, Shu, Hong-Bing
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.09.2014; Public Library of Science (PLoS)
• Subjects: Antiviral Agents - metabolism; Biological response modifiers; Biology and Life Sciences; Blotting, Western; Cells, Cultured; Genes; Health aspects; Humans; Immunity, Innate - immunology; Immunoenzyme Techniques; Immunoprecipitation; Interferon; Interferon Regulatory Factor-3 - genetics; Interferon Regulatory Factor-3 - metabolism; Interferon Type I - genetics; Interferon Type I - metabolism; Kinases; Medicine and Health Sciences; Membrane Proteins - genetics; Membrane Proteins - metabolism; Neoplasm Proteins - antagonists & inhibitors; Neoplasm Proteins - genetics; Neoplasm Proteins - metabolism; Nucleic acids; Protein Processing, Post-Translational; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger - genetics; RNA, Small Interfering - genetics; Sensors; Signal Transduction; Ubiquitin-Protein Ligases - antagonists & inhibitors; Ubiquitin-Protein Ligases - genetics; Ubiquitin-Protein Ligases - metabolism; Ubiquitination; Viral infections; Virus Activation; Virus diseases; Virus Diseases - immunology; Virus Diseases - virology; Virus Replication; Viruses - immunology

Viral infection triggers induction of type I interferons (IFNs), which are critical mediators of innate antiviral immune response. Mediator of IRF3 activation (MITA, also called STING) is an adapter essential for virus-triggered IFN induction pathways. How post-translational modifications regulate t...