The Activation of Phytophthora Effector Avr3b by Plant Cyclophilin is Required for the Nudix Hydrolase Activity of Avr3b

• Published in: PLoS pathogens Vol. 11; no. 8; p. e1005139
• Main Authors: Kong, Guanghui, Zhao, Yao, Jing, Maofeng, Huang, Jie, Yang, Jin, Xia, Yeqiang, Kong, Liang, Ye, Wenwu, Xiong, Qin, Qiao, Yongli, Dong, Suomeng, Ma, Wenbo, Wang, Yuanchao
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.08.2015; Public Library of Science (PLoS)
• Subjects: Amino Acid Sequence; Apoptosis; Blotting, Western; Cyclophilins - immunology; Cyclophilins - metabolism; Diseases and pests; Enzymes; Experiments; Genomes; Glycine max - parasitology; Health aspects; Host-Parasite Interactions - physiology; Hydrolases; Immunoprecipitation; Infections; Molecular Sequence Data; Nudix Hydrolases; Observations; Phytophthora - immunology; Phytophthora - metabolism; Phytophthora - pathogenicity; Plant Diseases - immunology; Plant Diseases - parasitology; Plant Immunity - physiology; Plant Proteins - immunology; Plant Proteins - metabolism; Plant-pathogen relationships; Proteins; Pyrophosphatases - immunology; Pyrophosphatases - metabolism; Soybean; Two-Hybrid System Techniques; Virulence; Water molds

Plant pathogens secrete an arsenal of effector proteins to impair host immunity. Some effectors possess enzymatic activities that can modify their host targets. Previously, we demonstrated that a Phytophthora sojae RXLR effector Avr3b acts as a Nudix hydrolase when expressed in planta; and this enzy...