Vitexin induces apoptosis through mitochondrial pathway and PI3K/Akt/mTOR signaling in human non-small cell lung cancer A549 cells

• Published in: Biological research Vol. 52; no. 1; p. 7
• Main Authors: Liu, Xiaoli, Jiang, Qingfeng, Liu, Huaimin, Luo, Suxia
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 23.02.2019; BioMed Central; Sociedad de Biología de Chile; BMC
• Subjects: 1-Phosphatidylinositol 3-kinase; AKT protein; Antitumor activity; Apoptosis; Bcl-2 protein; BIOLOGY; Cancer therapies; Cancer treatment; Caspase; Caspase-3; Chemotherapy; Cytochrome; Cytochrome c; Cytosol; Dehydrogenases; Flavonoids; Health aspects; Leukemia; Liver cancer; Lung cancer; Membrane potential; Mitochondria; Mitochondrial dysfunction; Non-small cell lung cancer; Non-small cell lung carcinoma; PI3K/Akt/mTOR signaling; Prognosis; Proteins; Small cell lung cancer; TOR protein; Toxicity; Vitexin; United States > US; China; Mitochondrial dysfunction; Vitexin; Non-small cell lung cancer; PI3K/Akt/mTOR signaling

Currently, the prognosis of patients with non-small cell lung cancer (NSCLC) remains dismal; hence, it is critical to identify effective anti-NSCLC agents with limited side effects. This study aimed to evaluate the therapeutic potential of flavonoid compound vitexin in human NSCLC cells and the unde...