Teaching Fido new ModiFICation tricks

  [...]the modification disrupts signaling by, or the function of, the target protein. [...]GTPases are common targets of Fic proteins, a logical choice since they typically have pivotal roles in cell signaling and physiology.

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Published inPLoS pathogens Vol. 10; no. 9; p. e1004349
Main Authors Cruz, Jonathan W, Woychik, Nancy A
Format Journal Article
LanguageEnglish
Published United States Public Library of Science 01.09.2014
Public Library of Science (PLoS)
Subjects
Adenosine
Adenylic acid
Amino acids
Animals
Bacterial Proteins - metabolism
Bacteriology
Biology and Life Sciences
Cell adhesion & migration
Chemokine CCL7 - metabolism
Cyclic AMP - metabolism
Cytotoxicity
Drosophila Proteins - metabolism
G proteins
Humans
Kinases
Medicine and Health Sciences
Nucleotidyltransferases - metabolism
Pearls
Phosphorylation
Phosphotransferases
Physiological aspects
Protein research
Proteins
Signal Transduction
Virulence (Microbiology)
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Abstract   [...]the modification disrupts signaling by, or the function of, the target protein. [...]GTPases are common targets of Fic proteins, a logical choice since they typically have pivotal roles in cell signaling and physiology.
AbstractList   [...]the modification disrupts signaling by, or the function of, the target protein. [...]GTPases are common targets of Fic proteins, a logical choice since they typically have pivotal roles in cell signaling and physiology.
Audience Academic
Author Cruz, Jonathan W
Woychik, Nancy A
AuthorAffiliation Department of Biochemistry and Molecular Biology, Rutgers University, Robert Wood Johnson Medical School, Piscataway, New Jersey, United States of America
University of North Carolina at Chapel Hill School of Medicine, United States of America
AuthorAffiliation_xml – name: University of North Carolina at Chapel Hill School of Medicine, United States of America
– name: Department of Biochemistry and Molecular Biology, Rutgers University, Robert Wood Johnson Medical School, Piscataway, New Jersey, United States of America
Author_xml – sequence: 1
  givenname: Jonathan W
  surname: Cruz
  fullname: Cruz, Jonathan W
  organization: Department of Biochemistry and Molecular Biology, Rutgers University, Robert Wood Johnson Medical School, Piscataway, New Jersey, United States of America
– sequence: 2
  givenname: Nancy A
  surname: Woychik
  fullname: Woychik, Nancy A
  organization: Department of Biochemistry and Molecular Biology, Rutgers University, Robert Wood Johnson Medical School, Piscataway, New Jersey, United States of America
BackLink https://www.ncbi.nlm.nih.gov/pubmed/25255332$$D View this record in MEDLINE/PubMed
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CitedBy_id crossref_primary_10_1146_annurev_micro_102215_095245
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Copyright COPYRIGHT 2014 Public Library of Science
2014 Cruz, Woychik 2014 Cruz, Woychik
2014 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Cruz JW, Woychik NA (2014) Teaching Fido New ModiFICation Tricks. PLoS Pathog 10(9): e1004349. doi:10.1371/journal.ppat.1004349
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Snippet   [...]the modification disrupts signaling by, or the function of, the target protein. [...]GTPases are common targets of Fic proteins, a logical choice since...
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StartPage e1004349
SubjectTerms Adenosine
Adenylic acid
Amino acids
Animals
Bacterial Proteins - metabolism
Bacteriology
Biology and Life Sciences
Cell adhesion & migration
Chemokine CCL7 - metabolism
Cyclic AMP - metabolism
Cytotoxicity
Drosophila Proteins - metabolism
G proteins
Humans
Kinases
Medicine and Health Sciences
Nucleotidyltransferases - metabolism
Pearls
Phosphorylation
Phosphotransferases
Physiological aspects
Protein research
Proteins
Signal Transduction
Virulence (Microbiology)
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Title Teaching Fido new ModiFICation tricks
URI https://www.ncbi.nlm.nih.gov/pubmed/25255332
https://search.proquest.com/docview/1566402073
https://pubmed.ncbi.nlm.nih.gov/PMC4177925
https://doaj.org/article/ae5f0cb5a1984a06ae5d6855d0e260fd
http://dx.doi.org/10.1371/journal.ppat.1004349
Volume 10
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