Supplementation of sodium butyrate protects mice from the development of non-alcoholic steatohepatitis (NASH)
Overnutrition, insulin resistance and an impaired intestinal barrier function are discussed as critical factors in the development of non-alcoholic fatty liver disease. Not only butyrate-producing probiotics as well as supplementation of sodium butyrate (SoB) have been suggested to bear protective e...
Saved in:
Published in | British journal of nutrition Vol. 114; no. 11; pp. 1745 - 1755 |
---|---|
Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Cambridge, UK
Cambridge University Press
14.12.2015
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Overnutrition, insulin resistance and an impaired intestinal barrier function are discussed as critical factors in the development of non-alcoholic fatty liver disease. Not only butyrate-producing probiotics as well as supplementation of sodium butyrate (SoB) have been suggested to bear protective effects on liver damage of various aetiologies. However, whether an oral consumption of SoB has a protective effect on Western-style diet (WSD)-induced non-alcoholic steatohepatitis (NASH) and if so molecular mechanism involved has not yet been determined. Eight-week-old C57BL/6J mice were pair-fed either a liquid control or WSD±0·6 g/kg body weight SoB. After 6 weeks, markers of liver damage, inflammation, toll-like receptor (TLR)-4 signalling, lipid peroxidation and glucose as well as lipid metabolism were determined in the liver tissue. Tight junction protein levels were determined in the duodenal tissue. SoB supplementation had no effects on the body weight gain or liver weight of WSD-fed mice, whereas liver steatosis and hepatic inflammation were significantly decreased (e.g. less inflammatory foci and neutrophils) when compared with mice fed only a WSD. Tight junction protein levels in duodenum, hepatic mRNA expression of TLR-4 and sterol regulatory element-binding protein 1c were altered similarly in both WSD groups when compared with controls, whereas protein levels of myeloid differentiation primary response gene 88, inducible nitric oxide synthase, 4-hydroxynonenal protein adducts and F4/80 macrophages were only significantly induced in livers of mice fed only the WSD. In summary, these data suggest that an oral supplementation of SoB protects mice from inflammation in the liver and thus from the development of WSD-induced NASH. |
---|---|
AbstractList | Overnutrition, insulin resistance and an impaired intestinal barrier function are discussed as critical factors in the development of non-alcoholic fatty liver disease. Not only butyrate-producing probiotics as well as supplementation of sodium butyrate (SoB) have been suggested to bear protective effects on liver damage of various aetiologies. However, whether an oral consumption of SoB has a protective effect on Western-style diet (WSD)-induced non-alcoholic steatohepatitis (NASH) and if so molecular mechanism involved has not yet been determined. Eight-week-old C57BL/6J mice were pair-fed either a liquid control or WSD±0·6 g/kg body weight SoB. After 6 weeks, markers of liver damage, inflammation, toll-like receptor (TLR)-4 signalling, lipid peroxidation and glucose as well as lipid metabolism were determined in the liver tissue. Tight junction protein levels were determined in the duodenal tissue. SoB supplementation had no effects on the body weight gain or liver weight of WSD-fed mice, whereas liver steatosis and hepatic inflammation were significantly decreased (e.g. less inflammatory foci and neutrophils) when compared with mice fed only a WSD. Tight junction protein levels in duodenum, hepatic mRNA expression of TLR-4 and sterol regulatory element-binding protein 1c were altered similarly in both WSD groups when compared with controls, whereas protein levels of myeloid differentiation primary response gene 88, inducible nitric oxide synthase, 4-hydroxynonenal protein adducts and F4/80 macrophages were only significantly induced in livers of mice fed only the WSD. In summary, these data suggest that an oral supplementation of SoB protects mice from inflammation in the liver and thus from the development of WSD-induced NASH. Overnutrition, insulin resistance and an impaired intestinal barrier function are discussed as critical factors in the development of non-alcoholic fatty liver disease. Not only butyrate-producing probiotics as well as supplementation of sodium butyrate (SoB) have been suggested to bear protective effects on liver damage of various aetiologies. However, whether an oral consumption of SoB has a protective effect on Western-style diet (WSD)-induced non-alcoholic steatohepatitis (NASH) and if so molecular mechanism involved has not yet been determined. Eight-week-old C57BL/6J mice were pair-fed either a liquid control or WSD plus or minus 0.6 g/kg body weight SoB. After 6 weeks, markers of liver damage, inflammation, toll-like receptor (TLR)-4 signalling, lipid peroxidation and glucose as well as lipid metabolism were determined in the liver tissue. Tight junction protein levels were determined in the duodenal tissue. SoB supplementation had no effects on the body weight gain or liver weight of WSD-fed mice, whereas liver steatosis and hepatic inflammation were significantly decreased (e.g. less inflammatory foci and neutrophils) when compared with mice fed only a WSD. Tight junction protein levels in duodenum, hepatic mRNA expression of TLR-4 and sterol regulatory element-binding protein 1c were altered similarly in both WSD groups when compared with controls, whereas protein levels of myeloid differentiation primary response gene 88, inducible nitric oxide synthase, 4-hydroxynonenal protein adducts and F4/80 macrophages were only significantly induced in livers of mice fed only the WSD. In summary, these data suggest that an oral supplementation of SoB protects mice from inflammation in the liver and thus from the development of WSD-induced NASH. Abstract Overnutrition, insulin resistance and an impaired intestinal barrier function are discussed as critical factors in the development of non-alcoholic fatty liver disease. Not only butyrate-producing probiotics as well as supplementation of sodium butyrate (SoB) have been suggested to bear protective effects on liver damage of various aetiologies. However, whether an oral consumption of SoB has a protective effect on Western-style diet (WSD)-induced non-alcoholic steatohepatitis (NASH) and if so molecular mechanism involved has not yet been determined. Eight-week-old C57BL/6J mice were pair-fed either a liquid control or WSD±0·6 g/kg body weight SoB. After 6 weeks, markers of liver damage, inflammation, toll-like receptor (TLR)-4 signalling, lipid peroxidation and glucose as well as lipid metabolism were determined in the liver tissue. Tight junction protein levels were determined in the duodenal tissue. SoB supplementation had no effects on the body weight gain or liver weight of WSD-fed mice, whereas liver steatosis and hepatic inflammation were significantly decreased (e.g. less inflammatory foci and neutrophils) when compared with mice fed only a WSD. Tight junction protein levels in duodenum, hepatic mRNA expression of TLR-4 and sterol regulatory element-binding protein 1c were altered similarly in both WSD groups when compared with controls, whereas protein levels of myeloid differentiation primary response gene 88, inducible nitric oxide synthase, 4-hydroxynonenal protein adducts and F4/80 macrophages were only significantly induced in livers of mice fed only the WSD. In summary, these data suggest that an oral supplementation of SoB protects mice from inflammation in the liver and thus from the development of WSD-induced NASH. |
Author | Sellmann, Cathrin Engstler, Anna Janina Ziegenhardt, Doreen Jin, Cheng Jun Bergheim, Ina |
Author_xml | – sequence: 1 givenname: Cheng Jun surname: Jin fullname: Jin, Cheng Jun organization: Institute of Nutritional Sciences, SD Model Systems of Molecular Nutrition, Friedrich-Schiller-University Jena, 07743 Jena, Germany – sequence: 2 givenname: Cathrin surname: Sellmann fullname: Sellmann, Cathrin organization: Institute of Nutritional Sciences, SD Model Systems of Molecular Nutrition, Friedrich-Schiller-University Jena, 07743 Jena, Germany – sequence: 3 givenname: Anna Janina surname: Engstler fullname: Engstler, Anna Janina organization: Institute of Nutritional Sciences, SD Model Systems of Molecular Nutrition, Friedrich-Schiller-University Jena, 07743 Jena, Germany – sequence: 4 givenname: Doreen surname: Ziegenhardt fullname: Ziegenhardt, Doreen organization: Institute of Nutritional Sciences, SD Model Systems of Molecular Nutrition, Friedrich-Schiller-University Jena, 07743 Jena, Germany – sequence: 5 givenname: Ina surname: Bergheim fullname: Bergheim, Ina email: ina.bergheim@uni-jena.de organization: Institute of Nutritional Sciences, SD Model Systems of Molecular Nutrition, Friedrich-Schiller-University Jena, 07743 Jena, Germany |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/26450277$$D View this record in MEDLINE/PubMed |
BookMark | eNqFkU9v1DAQxS1URLeFD8AFWeLSHkI9tmMnx6rqH6SKHhbOkdcZs6niONgOUr89jrogBEKcRqP5vTczeifkaAoTEvIW2AdgoC-2jDENIGuoGROKwwuyAanriivFj8hmHVfr_JicpPRY2gZY-4occyVrxrXeEL9d5nlEj1M2eQgTDY6m0A-Lp7slP0WTkc4xZLQ5UT9YpC4GT_MeaY_fcQzzKl1V5bbKjDbswzhYmjKaHPY4F9c8JHr26XJ7d_6avHRmTPjmUE_Jl5vrz1d31f3D7cery_vKKiFy1SjZilo1liHW0tmeCVQgLd852YBtXGtbRKd7rqXhGkz5xzLhZN9yZkGLU3L27FtO_7Zgyp0fksVxNBOGJXXQSCWhqOH_qBagW65VU9D3f6CPYYlTeaRQvNUaaq4KBc-UjSGliK6b4-BNfOqAdWts3V-xFc27g_Oy89j_UvzMqQDiYGr8Lg79V_xt9z9tfwAf9aLP |
CitedBy_id | crossref_primary_10_3389_fendo_2019_00611 crossref_primary_10_1016_j_aninu_2024_05_001 crossref_primary_10_4236_abb_2022_139024 crossref_primary_10_1002_mnfr_201600985 crossref_primary_10_1152_ajpgi_00245_2016 crossref_primary_10_1016_j_redox_2022_102528 crossref_primary_10_1111_jgh_15713 crossref_primary_10_3390_cells12172153 crossref_primary_10_3390_nu12103200 crossref_primary_10_3390_metabo13030322 crossref_primary_10_1016_j_phanu_2022_100316 crossref_primary_10_3389_fcimb_2024_1323261 crossref_primary_10_1080_10408398_2021_1966738 crossref_primary_10_3945_an_116_013151 crossref_primary_10_3390_biomedicines10030550 crossref_primary_10_3390_metabo13070859 crossref_primary_10_1093_advances_nmy013 crossref_primary_10_1111_jgh_13488 crossref_primary_10_1177_11786469211070533 crossref_primary_10_1016_j_redox_2023_102870 crossref_primary_10_3389_fmicb_2023_1123547 crossref_primary_10_1002_fsn3_1118 crossref_primary_10_1016_j_cbi_2016_06_007 crossref_primary_10_1016_j_lfs_2023_121614 crossref_primary_10_3390_nu12040951 crossref_primary_10_3390_life14050559 crossref_primary_10_3390_nu10091329 crossref_primary_10_1111_jgh_15899 crossref_primary_10_3389_fmicb_2020_567654 crossref_primary_10_1038_s41598_017_01751_y crossref_primary_10_3390_livers2030012 crossref_primary_10_1038_ijo_2017_52 crossref_primary_10_3390_nu9091013 crossref_primary_10_2174_1573401316999201029210912 crossref_primary_10_3389_fcimb_2021_683743 crossref_primary_10_1016_j_metop_2020_100043 crossref_primary_10_1016_j_procbio_2022_10_031 crossref_primary_10_1039_D0FO00178C crossref_primary_10_1017_S0007114519001399 crossref_primary_10_1038_s41598_019_43228_0 crossref_primary_10_1016_j_bbrc_2016_10_072 crossref_primary_10_3390_children4080066 crossref_primary_10_3389_fmicb_2018_01967 crossref_primary_10_1053_j_gastro_2016_02_073 crossref_primary_10_3748_wjg_v23_i1_60 crossref_primary_10_1016_j_foodchem_2020_127094 crossref_primary_10_3389_fcimb_2022_774335 crossref_primary_10_3390_nu9121348 crossref_primary_10_3945_jn_117_253815 crossref_primary_10_1038_s41419_023_05853_6 crossref_primary_10_1016_j_jnutbio_2023_109495 crossref_primary_10_1016_j_redox_2021_101879 crossref_primary_10_1371_journal_pone_0237946 crossref_primary_10_3390_ijms23063167 crossref_primary_10_1155_2019_9062537 crossref_primary_10_3748_wjg_v29_i4_597 crossref_primary_10_1177_09731296241228361 crossref_primary_10_1210_endocr_bqaa235 crossref_primary_10_1016_j_jep_2023_116811 crossref_primary_10_3748_wjg_v27_i18_2160 crossref_primary_10_3389_fnut_2022_1037696 crossref_primary_10_3390_ijms232415506 crossref_primary_10_1007_s00394_020_02431_w crossref_primary_10_1186_s12944_016_0289_1 crossref_primary_10_3390_nu11092156 crossref_primary_10_1111_jgh_15903 crossref_primary_10_3390_nu15040916 crossref_primary_10_1007_s00726_017_2423_4 crossref_primary_10_1016_j_imlet_2017_08_005 crossref_primary_10_1038_nrgastro_2016_85 crossref_primary_10_1098_rsob_230014 crossref_primary_10_1038_s41392_022_01119_3 crossref_primary_10_3390_ijms17040481 crossref_primary_10_3390_nu11081712 crossref_primary_10_4103_tcmj_tcmj_122_23 crossref_primary_10_3389_fcimb_2021_757718 crossref_primary_10_3390_metabo12020170 crossref_primary_10_1186_s12876_016_0451_2 crossref_primary_10_1186_s40643_023_00696_7 crossref_primary_10_1080_1744666X_2023_2294046 crossref_primary_10_14218_ERHM_2018_00025 crossref_primary_10_1136_gutjnl_2017_314050 crossref_primary_10_3390_biomedicines9121954 crossref_primary_10_1016_j_biopha_2022_114002 crossref_primary_10_3389_fnut_2023_1110536 crossref_primary_10_3390_biomedicines10010083 crossref_primary_10_1016_j_jnutbio_2018_10_020 crossref_primary_10_1038_s41598_020_64916_2 crossref_primary_10_1016_j_redox_2018_101092 crossref_primary_10_5812_hepatmon_92244 crossref_primary_10_1021_acs_jafc_8b01189 crossref_primary_10_1016_j_ajpath_2023_06_007 crossref_primary_10_1016_j_phrs_2019_04_002 crossref_primary_10_3390_nu13030959 crossref_primary_10_3389_fmicb_2022_1029890 crossref_primary_10_1016_j_bbadis_2017_07_003 crossref_primary_10_3389_fimmu_2022_968799 crossref_primary_10_1152_ajpgi_00345_2018 crossref_primary_10_3390_nu14091977 crossref_primary_10_1111_obr_13498 crossref_primary_10_1017_S0007114516004025 crossref_primary_10_1016_j_cellimm_2018_03_003 crossref_primary_10_1053_j_gastro_2022_09_012 crossref_primary_10_1016_j_metabol_2020_154283 |
Cites_doi | 10.2119/molmed.2012.00223 10.3164/jcbn.11-22 10.1002/hep.24001 10.1097/MCO.0b013e32835665fa 10.1093/alcalc/agv048 10.2337/db08-1637 10.1371/journal.pone.0068626 10.1093/ndt/gfr807 10.1084/jem.20122006 10.1002/hep.22848 10.1016/j.jhep.2008.01.035 10.3390/ijms151121069 10.5551/jat.15065 10.2527/jas.50965 10.1007/s10620-012-2112-9 10.1038/labinvest.2012.75 10.1017/S0007114511004983 10.3945/jn.113.179549 10.1002/hep.27395 10.1016/j.domaniend.2014.07.004 10.1016/j.jss.2013.08.028 10.1101/sqb.2013.78.021246 10.1097/MPG.0000000000000369 10.1007/s10620-005-1267-z 10.1016/j.jnutbio.2010.04.007 10.1016/j.jhep.2013.12.025 10.1016/S1499-3872(14)60044-8 10.1371/journal.pone.0063388 10.1111/liv.12442 10.1371/journal.pone.0106184 10.1111/acer.12428 10.1016/0092-8674(94)90234-8 10.1007/s10620-012-2259-4 10.1124/jpet.105.095042 10.1093/jn/138.8.1452 10.1016/j.jhep.2012.12.005 10.1002/hep.23122 10.1002/hep.24127 10.1089/ars.2010.3263 10.3390/ijms140611963 |
ContentType | Journal Article |
Copyright | Copyright © The Authors 2015 |
Copyright_xml | – notice: Copyright © The Authors 2015 |
DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 3V. 7QP 7RV 7T5 7X2 7X7 7XB 88E 8C1 8FE 8FH 8FI 8FJ 8FK 8G5 ABUWG AFKRA AN0 ATCPS AZQEC BENPR BHPHI CCPQU DWQXO FYUFA GHDGH GNUQQ GUQSH H94 HCIFZ K9. KB0 M0K M0S M1P M2O MBDVC NAPCQ PQEST PQQKQ PQUKI PRINS Q9U 7X8 |
DOI | 10.1017/S0007114515003621 |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef ProQuest Central (Corporate) Calcium & Calcified Tissue Abstracts Nursing & Allied Health Database Immunology Abstracts Agricultural Science Collection Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) Public Health Database ProQuest SciTech Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Research Library (Alumni Edition) ProQuest Central (Alumni) ProQuest Central British Nursing Database Agricultural & Environmental Science Collection ProQuest Central Essentials ProQuest Central Natural Science Collection ProQuest One Community College ProQuest Central Korea Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student Research Library Prep AIDS and Cancer Research Abstracts SciTech Premium Collection (Proquest) (PQ_SDU_P3) ProQuest Health & Medical Complete (Alumni) Nursing & Allied Health Database (Alumni Edition) Agriculture Science Database Health & Medical Collection (Alumni Edition) PML(ProQuest Medical Library) Research Library Research Library (Corporate) Nursing & Allied Health Premium ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China ProQuest Central Basic MEDLINE - Academic |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef Agricultural Science Database Research Library Prep ProQuest Central Student ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College Research Library (Alumni Edition) ProQuest Natural Science Collection ProQuest Central China ProQuest Central Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Agricultural & Environmental Science Collection AIDS and Cancer Research Abstracts ProQuest Research Library ProQuest Medical Library (Alumni) ProQuest Public Health ProQuest Central Basic ProQuest One Academic Eastern Edition Agricultural Science Collection British Nursing Index with Full Text ProQuest Nursing & Allied Health Source ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest SciTech Collection ProQuest Hospital Collection (Alumni) Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition Immunology Abstracts ProQuest Nursing & Allied Health Source (Alumni) ProQuest One Academic Calcium & Calcified Tissue Abstracts ProQuest Central (Alumni) MEDLINE - Academic |
DatabaseTitleList | MEDLINE - Academic Calcium & Calcified Tissue Abstracts CrossRef MEDLINE Agricultural Science Database |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 3 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Diet & Clinical Nutrition |
DocumentTitleAlternate | C. J. Jin et al. Sodium butyrate and liver disease |
EISSN | 1475-2662 |
EndPage | 1755 |
ExternalDocumentID | 3857001871 10_1017_S0007114515003621 26450277 |
Genre | Research Support, Non-U.S. Gov't Journal Article Feature |
GroupedDBID | --- -1D -2P -E. -~6 -~X .FH 09C 09E 0E1 0R~ 23N 2WC 3V. 4.4 5GY 5RE 5VS 6J9 6PF 74X 74Y 7RV 7X2 7X7 7~V 88E 8C1 8FE 8FH 8FI 8FJ 8G5 8R4 8R5 9M5 AAAZR AABES AABWE AACJH AAFWJ AAGFV AAIKC AAKTX AAMNQ AAMNW AARAB AASVR AATID AAUIS AAUKB AAWTL AAZAQ ABBJB ABBXD ABFBI ABGDZ ABJNI ABKKG ABKMT ABMWE ABQTM ABROB ABUWG ABVZP ABWCF ABZCX ACBEK ACBMC ACGFS ACIMK ACPRK ACUIJ ACYZP ACZBM ACZUX ACZWT ADAZD ADBBV ADDNB ADFEC ADFRT ADKIL ADVJH AEBAK AEHGV AEMTW AENEX AEPLO AEYHU AEYYC AFFUJ AFKQG AFKRA AFLOS AFLVW AFOSN AFRAH AFRIC AFUTZ AGABE AGJUD AGLWM AHIPN AHLTW AHMBA AHQXX AHRGI AIGNW AIHIV AIOIP AISIE AJ7 AJCYY AJPFC AJQAS ALMA_UNASSIGNED_HOLDINGS ALWZO AN0 ANPSP AQJOH ARABE ATCPS ATUCA AUXHV AYIQA AZGZS AZQEC BAWUL BBLKV BENPR BHPHI BKEYQ BLZWO BMAJL BNQBC BPHCQ BRIRG BVXVI C0O CBIIA CCPQU CCQAD CFAFE CHEAL CJCSC CS3 DIK DOHLZ DU5 DWQXO E3Z EBS EJD EX3 F5P FYUFA GNUQQ GUQSH HCIFZ HG- HH5 HMCUK HST HZ~ I.6 I.7 IH6 IOEEP IOO IS6 I~P J36 J38 J3A JHPGK JKPOH JQKCU JVRFK KCGVB KFECR L7B L98 LHUNA LW7 M-V M0K M1P M2O M7~ NAPCQ NIKVX O9- OK1 OVD P6G PCD PQQKQ PROAC PSQYO Q2X RAMDC RCA RIG ROL RR0 S6- S6U SAAAG SJN SY4 T9M TEORI TR2 UCJ UKHRP UT1 UU6 WFFJZ WH7 WOW WQ3 WXU WYP Y6R ZA5 ZMEZD ZYDXJ ~KM AAHBH ABXAU AENGE CGR CUY CVF ECM EIF NPM AAYXX CITATION 7QP 7T5 7XB 8FK H94 K9. MBDVC PQEST PQUKI PRINS Q9U 7X8 |
ID | FETCH-LOGICAL-c633t-86493568c0ee54fcd03e614c2bf481c8f9c9eef7d274a271a264c03f4d920c173 |
IEDL.DBID | BENPR |
ISSN | 0007-1145 |
IngestDate | Sat Aug 17 02:39:58 EDT 2024 Fri Aug 16 21:31:47 EDT 2024 Tue Sep 24 20:02:06 EDT 2024 Thu Sep 26 17:28:52 EDT 2024 Sat Sep 28 07:57:14 EDT 2024 Thu May 09 22:59:22 EDT 2024 |
IsDoiOpenAccess | false |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 11 |
Keywords | Sodium butyrate Reactive oxygen species Hepatic inflammation Non-alcoholic fatty liver disease Inducible nitric oxide synthase |
Language | English |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c633t-86493568c0ee54fcd03e614c2bf481c8f9c9eef7d274a271a264c03f4d920c173 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
OpenAccessLink | https://www.cambridge.org/core/services/aop-cambridge-core/content/view/18FA7DCBAA081AF33D8BFB933D88A73D/S0007114515003621a.pdf/div-class-title-supplementation-of-sodium-butyrate-protects-mice-from-the-development-of-non-alcoholic-steatohepatitis-nash-div.pdf |
PMID | 26450277 |
PQID | 1729771526 |
PQPubID | 5629 |
PageCount | 11 |
ParticipantIDs | proquest_miscellaneous_1846412741 proquest_miscellaneous_1731792768 proquest_journals_1729771526 crossref_primary_10_1017_S0007114515003621 pubmed_primary_26450277 cambridge_journals_10_1017_S0007114515003621 |
PublicationCentury | 2000 |
PublicationDate | 2015-12-14 |
PublicationDateYYYYMMDD | 2015-12-14 |
PublicationDate_xml | – month: 12 year: 2015 text: 2015-12-14 day: 14 |
PublicationDecade | 2010 |
PublicationPlace | Cambridge, UK |
PublicationPlace_xml | – name: Cambridge, UK – name: England – name: Cambridge |
PublicationTitle | British journal of nutrition |
PublicationTitleAlternate | Br J Nutr |
PublicationYear | 2015 |
Publisher | Cambridge University Press |
Publisher_xml | – name: Cambridge University Press |
References | Tacke, Zimmermann (24) 2014; 60 Brunt, Kleiner, Wilson (12) 2011; 53 Spruss, Kanuri, Wagnerberger (16) 2009; 50 Spruss, Kanuri, Stahl (11) 2012; 92 Ohira, Fujioka, Katagiri (28) 2012; 50 Ohira, Fujioka, Katagiri (25) 2013; 20 Blachier, Leleu, Peck-Radosavljevic (2) 2013; 58 Tilg, Moschen (22) 2010; 52 Ma, Fan, Li (36) 2012; 90 Sass, Chang, Chopra (1) 2005; 50 Endo, Niioka, Kobayashi (39) 2013; 8 Maximos, Bril, Portillo (29) 2015; 61 Volynets, Kuper, Strahl (37) 2012; 57 Mattace, Simeoli, Russo (6) 2013; 8 Elamin, Masclee, Dekker (4) 2013; 143 Ben-Sasson, Wang, Cohen (26) 2013; 78 Leonel, Alvarez-Leite (3) 2012; 15 Wang, Sato, Brown (40) 1994; 77 Qiao, Qian, Wang (7) 2014; 187 Miele, Valenza, La (33) 2009; 49 Liu, Qian, Wang (38) 2014; 9 Machado, Constantino, Tomasi (23) 2012; 27 Bergheim (15) 2008; 48 Landmann, Wagnerberger, Kanuri (18) 2015; 50 Thuy, Ladurner, Volynets (34) 2008; 138 Wang, Wang, Wang (35) 2012; 57 Yang, Wang, Li (19) 2014; 13 Bergheim, Guo, Davis (13) 2006; 316 Cresci, Bush, Nagy (9) 2014; 38 Kanuri, Bergheim (21) 2013; 14 Huang, Li, Zhu (5) 2014; 59 Wagnerberger, Spruss, Kanuri (14) 2012; 107 Ben-Sasson, Hogg, Hu-Li (27) 2013; 210 Gao, Yin, Zhang (30) 2009; 58 Matis, Kulcsar, Turowski (31) 2015; 50 Sun, Wu, Sun (8) 2014; 15 Spruss, Kanuri, Uebel (20) 2011; 14 Kanuri, Ladurner, Skibovskaya (32) 2015; 35 Kanuri, Spruss, Wagnerberger (17) 2011; 22 Spruss, Henkel, Kanuri (10) 2012; 18 S0007114515003621_ref4 S0007114515003621_ref16 S0007114515003621_ref38 S0007114515003621_ref3 S0007114515003621_ref17 S0007114515003621_ref39 S0007114515003621_ref14 S0007114515003621_ref2 S0007114515003621_ref36 S0007114515003621_ref15 S0007114515003621_ref37 S0007114515003621_ref1 S0007114515003621_ref18 S0007114515003621_ref19 S0007114515003621_ref30 S0007114515003621_ref31 S0007114515003621_ref12 S0007114515003621_ref35 S0007114515003621_ref13 S0007114515003621_ref10 S0007114515003621_ref32 S0007114515003621_ref33 S0007114515003621_ref11 Thuy (S0007114515003621_ref34) 2008; 138 S0007114515003621_ref27 S0007114515003621_ref28 S0007114515003621_ref25 S0007114515003621_ref26 S0007114515003621_ref29 S0007114515003621_ref20 S0007114515003621_ref40 S0007114515003621_ref23 S0007114515003621_ref24 S0007114515003621_ref21 S0007114515003621_ref22 S0007114515003621_ref9 S0007114515003621_ref8 S0007114515003621_ref7 S0007114515003621_ref6 S0007114515003621_ref5 |
References_xml | – volume: 50 start-page: 171 year: 2005 end-page: 180 ident: 1 article-title: Nonalcoholic fatty liver disease: a clinical review publication-title: Dig Dis Sci contributor: fullname: Chopra – volume: 20 start-page: 425 year: 2013 end-page: 442 ident: 25 article-title: Butyrate attenuates inflammation and lipolysis generated by the interaction of adipocytes and macrophages publication-title: J Atheroscler Thromb contributor: fullname: Katagiri – volume: 58 start-page: 1509 year: 2009 end-page: 1517 ident: 30 article-title: Butyrate improves insulin sensitivity and increases energy expenditure in mice publication-title: Diabetes contributor: fullname: Zhang – volume: 210 start-page: 491 year: 2013 end-page: 502 ident: 27 article-title: IL-1 enhances expansion, effector function, tissue localization, and memory response of antigen-specific CD8 T cells publication-title: J Exp Med contributor: fullname: Hu-Li – volume: 8 start-page: e68626 year: 2013 ident: 6 article-title: Effects of sodium butyrate and its synthetic amide derivative on liver inflammation and glucose tolerance in an animal model of steatosis induced by high fat diet publication-title: PLOS ONE contributor: fullname: Russo – volume: 59 start-page: 264 year: 2014 end-page: 269 ident: 5 article-title: Inhibition of p38 mitogen-activated protein kinase attenuates butyrate-induced intestinal barrier impairment in a Caco-2 cell monolayer model publication-title: J Pediatr Gastroenterol Nutr contributor: fullname: Zhu – volume: 187 start-page: 653 year: 2014 end-page: 659 ident: 7 article-title: Butyrate protects liver against ischemia reperfusion injury by inhibiting nuclear factor kappa B activation in Kupffer cells publication-title: J Surg Res contributor: fullname: Wang – volume: 14 start-page: 2121 year: 2011 end-page: 2135 ident: 20 article-title: Role of the inducible nitric oxide synthase in the onset of fructose-induced steatosis in mice publication-title: Antioxid Redox Signal contributor: fullname: Uebel – volume: 143 start-page: 1872 year: 2013 end-page: 1881 ident: 4 article-title: Short-chain fatty acids activate AMP-activated protein kinase and ameliorate ethanol-induced intestinal barrier dysfunction in Caco-2 cell monolayers publication-title: J Nutr contributor: fullname: Dekker – volume: 90 start-page: 266 issue: Suppl. 4 year: 2012 end-page: 268 ident: 36 article-title: Butyrate promotes the recovering of intestinal wound healing through its positive effect on the tight junctions publication-title: J Anim Sci contributor: fullname: Li – volume: 50 start-page: 493 year: 2015 end-page: 500 ident: 18 article-title: Beer is less harmful for the liver than plain ethanol: studies in male mice using a binge-drinking model publication-title: Alcohol Alcohol contributor: fullname: Kanuri – volume: 57 start-page: 3126 year: 2012 end-page: 3135 ident: 35 article-title: Butyrate enhances intestinal epithelial barrier function via up-regulation of tight junction protein Claudin-1 transcription publication-title: Dig Dis Sci contributor: fullname: Wang – volume: 14 start-page: 11963 year: 2013 end-page: 11980 ident: 21 article-title: In vitro and in vivo models of non-alcoholic fatty liver disease (NAFLD) publication-title: Int J Mol Sci contributor: fullname: Bergheim – volume: 50 start-page: 26 year: 2015 end-page: 31 ident: 31 article-title: Effects of oral butyrate application on insulin signaling in various tissues of chickens publication-title: Domest Anim Endocrinol contributor: fullname: Turowski – volume: 107 start-page: 1727 year: 2012 end-page: 1738 ident: 14 article-title: Toll-like receptors 1-9 are elevated in livers with fructose-induced hepatic steatosis publication-title: Br J Nutr contributor: fullname: Kanuri – volume: 18 start-page: 1346 year: 2012 end-page: 1355 ident: 10 article-title: Female mice are more susceptible to nonalcoholic fatty liver disease: sex-specific regulation of the hepatic AMP-activated protein kinase-plasminogen activator inhibitor 1 cascade, but not the hepatic endotoxin response publication-title: Mol Med contributor: fullname: Kanuri – volume: 22 start-page: 527 year: 2011 end-page: 534 ident: 17 article-title: Role of tumor necrosis factor alpha (TNFalpha) in the onset of fructose-induced nonalcoholic fatty liver disease in mice publication-title: J Nutr Biochem contributor: fullname: Wagnerberger – volume: 15 start-page: 21069 year: 2014 end-page: 21079 ident: 8 article-title: Inhibition of histone deacetylase by butyrate protects rat liver from ischemic reperfusion injury publication-title: Int J Mol Sci contributor: fullname: Sun – volume: 52 start-page: 1836 year: 2010 end-page: 1846 ident: 22 article-title: Evolution of inflammation in nonalcoholic fatty liver disease: the multiple parallel hits hypothesis publication-title: Hepatology contributor: fullname: Moschen – volume: 15 start-page: 474 year: 2012 end-page: 479 ident: 3 article-title: Butyrate: implications for intestinal function publication-title: Curr Opin Clin Nutr Metab Care contributor: fullname: Alvarez-Leite – volume: 50 start-page: 59 year: 2012 end-page: 66 ident: 28 article-title: Butyrate enhancement of inteleukin-1beta production via activation of oxidative stress pathways in lipopolysaccharide-stimulated THP-1 cells publication-title: J Clin Biochem Nutr contributor: fullname: Katagiri – volume: 38 start-page: 1489 year: 2014 end-page: 1501 ident: 9 article-title: Tributyrin supplementation protects mice from acute ethanol-induced gut injury publication-title: Alcohol Clin Exp Res contributor: fullname: Nagy – volume: 53 start-page: 810 year: 2011 end-page: 820 ident: 12 article-title: Nonalcoholic fatty liver disease (NAFLD) activity score and the histopathologic diagnosis in NAFLD: distinct clinicopathologic meanings publication-title: Hepatology contributor: fullname: Wilson – volume: 60 start-page: 1090 year: 2014 end-page: 1096 ident: 24 article-title: Macrophage heterogeneity in liver injury and fibrosis publication-title: J Hepatol contributor: fullname: Zimmermann – volume: 78 start-page: 117 year: 2013 end-page: 124 ident: 26 article-title: IL-1beta strikingly enhances antigen-driven CD4 and CD8 T-cell responses publication-title: Cold Spring Harb Symp Quant Biol contributor: fullname: Cohen – volume: 57 start-page: 1932 year: 2012 end-page: 1941 ident: 37 article-title: Nutrition, intestinal permeability, and blood ethanol levels are altered in patients with nonalcoholic fatty liver disease (NAFLD) publication-title: Dig Dis Sci contributor: fullname: Strahl – volume: 138 start-page: 1452 year: 2008 end-page: 1455 ident: 34 article-title: Nonalcoholic fatty liver disease in humans is associated with increased plasma endotoxin and plasminogen activator inhibitor 1 concentrations and with fructose intake publication-title: J Nutr contributor: fullname: Volynets – volume: 48 start-page: 983 year: 2008 end-page: 992 ident: 15 article-title: Antibiotics protect against fructose-induced hepatic lipid accumulation in mice: role of endotoxin publication-title: J Hepatol contributor: fullname: Bergheim – volume: 35 start-page: 562 year: 2015 end-page: 568 ident: 32 article-title: Expression of toll-like receptors 1-5 but not TLR 6-10 is elevated in livers of patients with non-alcoholic fatty liver disease publication-title: Liver Int contributor: fullname: Skibovskaya – volume: 9 start-page: e106184 year: 2014 ident: 38 article-title: Butyrate protects rat liver against total hepatic ischemia reperfusion injury with bowel congestion publication-title: PLOS ONE contributor: fullname: Wang – volume: 77 start-page: 53 year: 1994 end-page: 62 ident: 40 article-title: SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis publication-title: Cell contributor: fullname: Brown – volume: 316 start-page: 592 year: 2006 end-page: 600 ident: 13 article-title: Critical role of plasminogen activator inhibitor-1 in cholestatic liver injury and fibrosis publication-title: J Pharmacol Exp Ther contributor: fullname: Davis – volume: 27 start-page: 3136 year: 2012 end-page: 3140 ident: 23 article-title: Sodium butyrate decreases the activation of NF-kappa B reducing inflammation and oxidative damage in the kidney of rats subjected to contrast-induced nephropathy publication-title: Nephrol Dial Transplant contributor: fullname: Tomasi – volume: 13 start-page: 309 year: 2014 end-page: 315 ident: 19 article-title: Sodium butyrate protects against toxin-induced acute liver failure in rats publication-title: Hepatobiliary Pancreat Dis Int contributor: fullname: Li – volume: 50 start-page: 1094 year: 2009 end-page: 1104 ident: 16 article-title: Toll-like receptor 4 is involved in the development of fructose-induced hepatic steatosis in mice publication-title: Hepatology contributor: fullname: Wagnerberger – volume: 8 start-page: e63388 year: 2013 ident: 39 article-title: Butyrate-producing probiotics reduce nonalcoholic fatty liver disease progression in rats: new insight into the probiotics for the gut-liver axis publication-title: PLOS ONE contributor: fullname: Kobayashi – volume: 92 start-page: 1020 year: 2012 end-page: 1032 ident: 11 article-title: Metformin protects against the development of fructose-induced steatosis in mice: role of the intestinal barrier function publication-title: Lab Invest contributor: fullname: Stahl – volume: 58 start-page: 593 year: 2013 end-page: 608 ident: 2 article-title: The burden of liver disease in Europe: a review of available epidemiological data publication-title: J Hepatol contributor: fullname: Peck-Radosavljevic – volume: 61 start-page: 153 year: 2015 end-page: 160 ident: 29 article-title: The role of liver fat and insulin resistance as determinants of plasma aminotransferase elevation in nonalcoholic fatty liver disease publication-title: Hepatology contributor: fullname: Portillo – volume: 49 start-page: 1877 year: 2009 end-page: 1887 ident: 33 article-title: Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease publication-title: Hepatology contributor: fullname: La – ident: S0007114515003621_ref10 doi: 10.2119/molmed.2012.00223 – ident: S0007114515003621_ref28 doi: 10.3164/jcbn.11-22 – ident: S0007114515003621_ref22 doi: 10.1002/hep.24001 – ident: S0007114515003621_ref3 doi: 10.1097/MCO.0b013e32835665fa – ident: S0007114515003621_ref18 doi: 10.1093/alcalc/agv048 – ident: S0007114515003621_ref30 doi: 10.2337/db08-1637 – ident: S0007114515003621_ref6 doi: 10.1371/journal.pone.0068626 – ident: S0007114515003621_ref23 doi: 10.1093/ndt/gfr807 – ident: S0007114515003621_ref27 doi: 10.1084/jem.20122006 – ident: S0007114515003621_ref33 doi: 10.1002/hep.22848 – ident: S0007114515003621_ref15 doi: 10.1016/j.jhep.2008.01.035 – ident: S0007114515003621_ref8 doi: 10.3390/ijms151121069 – ident: S0007114515003621_ref25 doi: 10.5551/jat.15065 – ident: S0007114515003621_ref36 doi: 10.2527/jas.50965 – ident: S0007114515003621_ref37 doi: 10.1007/s10620-012-2112-9 – ident: S0007114515003621_ref11 doi: 10.1038/labinvest.2012.75 – ident: S0007114515003621_ref14 doi: 10.1017/S0007114511004983 – ident: S0007114515003621_ref4 doi: 10.3945/jn.113.179549 – ident: S0007114515003621_ref29 doi: 10.1002/hep.27395 – ident: S0007114515003621_ref31 doi: 10.1016/j.domaniend.2014.07.004 – ident: S0007114515003621_ref7 doi: 10.1016/j.jss.2013.08.028 – ident: S0007114515003621_ref26 doi: 10.1101/sqb.2013.78.021246 – ident: S0007114515003621_ref5 doi: 10.1097/MPG.0000000000000369 – ident: S0007114515003621_ref1 doi: 10.1007/s10620-005-1267-z – ident: S0007114515003621_ref17 doi: 10.1016/j.jnutbio.2010.04.007 – ident: S0007114515003621_ref24 doi: 10.1016/j.jhep.2013.12.025 – ident: S0007114515003621_ref19 doi: 10.1016/S1499-3872(14)60044-8 – ident: S0007114515003621_ref39 doi: 10.1371/journal.pone.0063388 – ident: S0007114515003621_ref32 doi: 10.1111/liv.12442 – ident: S0007114515003621_ref38 doi: 10.1371/journal.pone.0106184 – ident: S0007114515003621_ref9 doi: 10.1111/acer.12428 – ident: S0007114515003621_ref40 doi: 10.1016/0092-8674(94)90234-8 – ident: S0007114515003621_ref35 doi: 10.1007/s10620-012-2259-4 – ident: S0007114515003621_ref13 doi: 10.1124/jpet.105.095042 – volume: 138 start-page: 1452 year: 2008 ident: S0007114515003621_ref34 article-title: Nonalcoholic fatty liver disease in humans is associated with increased plasma endotoxin and plasminogen activator inhibitor 1 concentrations and with fructose intake publication-title: J Nutr doi: 10.1093/jn/138.8.1452 contributor: fullname: Thuy – ident: S0007114515003621_ref2 doi: 10.1016/j.jhep.2012.12.005 – ident: S0007114515003621_ref16 doi: 10.1002/hep.23122 – ident: S0007114515003621_ref12 doi: 10.1002/hep.24127 – ident: S0007114515003621_ref20 doi: 10.1089/ars.2010.3263 – ident: S0007114515003621_ref21 doi: 10.3390/ijms140611963 |
SSID | ssj0008109 |
Score | 2.520228 |
Snippet | Overnutrition, insulin resistance and an impaired intestinal barrier function are discussed as critical factors in the development of non-alcoholic fatty liver... Abstract Overnutrition, insulin resistance and an impaired intestinal barrier function are discussed as critical factors in the development of non-alcoholic... |
SourceID | proquest crossref pubmed cambridge |
SourceType | Aggregation Database Index Database Publisher |
StartPage | 1745 |
SubjectTerms | Animals Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Biomarkers - metabolism Butyric Acid - therapeutic use Diet, Western - adverse effects Dietary Supplements Duodenum - immunology Duodenum - metabolism Duodenum - pathology Female Gastrointestinal Agents - therapeutic use Gene Expression Regulation Hepatitis Immunohistochemistry Intestinal Mucosa - immunology Intestinal Mucosa - metabolism Intestinal Mucosa - pathology Lipid Peroxidation Liver - immunology Liver - metabolism Liver - pathology Mice, Inbred C57BL Molecular Nutrition Neutrophil Infiltration Non-alcoholic Fatty Liver Disease - immunology Non-alcoholic Fatty Liver Disease - metabolism Non-alcoholic Fatty Liver Disease - pathology Non-alcoholic Fatty Liver Disease - prevention & control Nutrition research Rodents Signal Transduction Tight Junction Proteins - genetics Tight Junction Proteins - metabolism Toll-Like Receptor 4 - antagonists & inhibitors Toll-Like Receptor 4 - genetics Toll-Like Receptor 4 - metabolism |
Title | Supplementation of sodium butyrate protects mice from the development of non-alcoholic steatohepatitis (NASH) |
URI | https://www.cambridge.org/core/product/identifier/S0007114515003621/type/journal_article https://www.ncbi.nlm.nih.gov/pubmed/26450277 https://www.proquest.com/docview/1729771526/abstract/ https://search.proquest.com/docview/1731792768 https://search.proquest.com/docview/1846412741 |
Volume | 114 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwEB71ceGCeBMolZEQAoS1cWIn8QmV0mqFxAoBlfa2iu2JuhLdFDZ76L_vTF4UVd1LDomTWJ6x5xvP-BuAN4RgLSqPMg4JSk0IXzryG6RXBpl9pfCBHcVvs2x6pr_OzXwHpsNZGE6rHNbEdqEOtec98gkZWoIqZG2ySel4F8A3k0-XfyTXj-I4a19MYxf2E6U5YLv_-WT2_ce4KheqT_dgUkSlzRDhbOmj2dByyVrT0rOomzwL_9urO0Boa4xOH8D9HkWKo07sD2EHV48g-rLERrwVPdXnbzEbmPYfw0VbvbPLFOc7oq7Eug7LzYVwm-aK-SJET9mwFlyhXvC5E0HoUIR_aUX81qpeybKrq7v0gnWkqc-R87Kb5Vq8mx39nL5_AmenJ7-Op7KvtCB9lqaNLDJtU5MVPkY0uvIhTpHstk9cpQvli8p6i1jlgXzYMslVSTDKx2mlg01ir_L0KezR7_E5iBKVyl0cTGKdLh0WPiOPqvRV4jDY2EbwcRzbRT9f1osu1yxf3BJFBB-G4V9cdvwb2xofDAK68elRcSJ4PT6mScSRkXKF9YbbEIyyCSnuljaE1LRitp8InnXCH3tEw2E4GP5iewdewj3CW4azYZQ-gL3m7wZfEaZp3CHs5vOcrsWxOuxV9xoa6vOn |
link.rule.ids | 315,786,790,12083,12250,21416,27957,27958,31754,31755,33301,33302,33779,33780,43345,43614,43840,74102,74371,74659 |
linkProvider | ProQuest |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3Nb9UwDLfg7QAXxDeFAUFCCBARTZv044QGbHrAViHYpN2qNnHFk9jroH0H_nvsNi1DiHdt0zaynfjn2P0Z4Ckh2ByVRRm6CKUmhC9rihukVQaZfSWzjgPFoyJZnuiPp-bUH7h1vqxy2hOHjdq1ls_IX5OjJahC3iZ5c_5Dctcozq76FhqXYUfHFKosYOftfvH5y7wXZ8oXeTAVotJmymsOpNHsXrlRrRlIWdRFdoW_vdR_oOfggg6uwzWPHcXeqOwbcAnXNyF4v8JePBOe4PO7KCZ-_VtwNvTsHOvD-YpoG9G1brU5E_Wm_8UsEcITNXSC-9IL_ttEECYU7k8xET-1bteyGrvprqxgy-jbb8jV2P2qE8-Lva_LF7fh5GD_-N1S-v4K0iZx3Mss0XlsksyGiEY31oUxkre2Ud3oTNmsyW2O2KSOItcqSlVF4MmGcaNdHoVWpfEdWNDn8R6ICpVK69CZKK91VWNmE4qjKttENbo8zAN4Ncu29KukK8cKs7T8RxUBvJzEX56PrBvbBu9OCrrw6tlcAngy36alw_mQao3thscQeMojMtctYwifacUcPwHcHZU_z4jEYTgFfn_7BB7DleXx0WF5-KH49ACuEuIyXA-j9C4s-p8bfEiopq8fedP9DWnO8SY |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3da9RAEB-0gvhS_G5q1RVEVFyaTXaT7JOU1uP8OgQt9C0kuxM8sJdqcg_-984km2tFvNdk88HO7M5vMr_8BuA5IViLyqGMfYJSE8KXNeUN0imDrL5SOM-J4udFNj_VH87MWeA_dYFWOe2Jw0btW8ffyA8p0BJUoWiTHTaBFvHlZPb24qfkDlJcaQ3tNK7DDYqKOS_S4viS7lGoQPdgUUSlzVThHOSjOdByy1ozyLOoqzoLf8er_4DQIRjNbsNuQJHiaDT7HbiGq7sQnSyxFy9EkPr8IRaT0v49OB-6d45McT4i2kZ0rV-uz0W97n-zXoQIkg2d4A71gv87EYQOhb-kFfFVq3Ylq7Gv7tIJ9pG-_Y7My-6XnXi5OPo6f3UfTmfvvh3PZei0IF2Wpr0sMm1TkxUuRjS6cT5OkeK2S-pGF8oVjXUWsck95bBVkquKYJSL00Z7m8RO5ekD2KHH4x6ICpXK69ibxNa6qrFwGWVUlWuSGr2NbQRvNnNbhvXSlSPXLC__MUUEr6fpLy9G_Y1tgw8mA1259cZxIni2OU2LiCsj1QrbNY8hGGUTctwtYwipacVqPxE8HI2_eSOaDsPF8P3tL_AUbpLPlp_eLz4-glsEvQwTY5Q-gJ3-1xofE7zp6yeD3_4BfNHzwA |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Supplementation+of+sodium+butyrate+protects+mice+from+the+development+of+non-alcoholic+steatohepatitis+%28NASH%29&rft.jtitle=British+journal+of+nutrition&rft.au=Jin%2C+Cheng+Jun&rft.au=Sellmann%2C+Cathrin&rft.au=Engstler%2C+Anna+Janina&rft.au=Ziegenhardt%2C+Doreen&rft.date=2015-12-14&rft.issn=0007-1145&rft.eissn=1475-2662&rft.volume=114&rft.issue=11&rft.spage=1745&rft.epage=1755&rft_id=info:doi/10.1017%2FS0007114515003621&rft.externalDBID=n%2Fa&rft.externalDocID=10_1017_S0007114515003621 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0007-1145&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0007-1145&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0007-1145&client=summon |