HIV Protective KIR3DL1/S1-HLA-B Genotypes Influence NK Cell-Mediated Inhibition of HIV Replication in Autologous CD4 Targets

• Published in: PLoS pathogens Vol. 10; no. 1; p. e1003867
• Main Authors: Song, Rujun, Lisovsky, Irene, Lebouché, Bertrand, Routy, Jean-Pierre, Bruneau, Julie, Bernard, Nicole F.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.01.2014; Public Library of Science (PLoS)
• Subjects: Acquired immune deficiency syndrome; Adult; Aged; AIDS; Antigens; Biology; CD4-Positive T-Lymphocytes - immunology; CD4-Positive T-Lymphocytes - pathology; CD4-Positive T-Lymphocytes - virology; Female; Genetic aspects; Genetic research; Genotype; Health aspects; HIV; HIV (Viruses); HIV Infections - genetics; HIV Infections - immunology; HIV Infections - pathology; HIV-1 - physiology; HLA-B Antigens - genetics; HLA-B Antigens - immunology; Human immunodeficiency virus; Humans; Immune system; Immunity, Cellular; Killer cells; Killer Cells, Natural - immunology; Killer Cells, Natural - pathology; Male; Medical research; Medicine; Microbiological research; Middle Aged; Receptors, KIR3DL1 - genetics; Receptors, KIR3DL1 - immunology; Virus Replication - genetics; Virus Replication - immunology; Canada

Carriage of the genetic combination encoding a high expression inhibitory Killer Immunoglobulin-like Receptor (KIR)3DL1 with its ligand, HLA-B*57 (*h/*y+B*57) is associated with slower time to AIDS and better HIV viral load control than being a Bw6 homozygote (Bw6hmz). Natural Killer (NK) cells from...