Pharmacological inhibition of mTORC1 activity protects against inflammation-induced apoptosis of nucleus pulposus cells

• Published in: Brazilian journal of medical and biological research Vol. 54; no. 5; p. e10185
• Main Authors: Chen, Rigao, Yang, Fei, Wang, Yong, Wang, Xinling, Fan, Xiaohong
• Format: Journal Article
• Language: English
• Published: Brazil Associacao Brasileira de Divulgacao Cientifica (ABDC) 01.01.2021; Revista Brasileira de Pesquisas Medicas; Associação Brasileira de Divulgação Científica
• Subjects: Acid production; Apoptosis; BIOLOGY; Cell survival; Cytokines; Degeneration; Development and progression; Dextrose; Glucose; Glucose metabolism; Homeostasis; Humans; Inflammation; Inflammation - drug therapy; Intervertebral disc degeneration; Intervertebral Disc Degeneration - drug therapy; Intervertebral discs; Lactic acid; Mechanistic Target of Rapamycin Complex 1; MEDICINE, RESEARCH & EXPERIMENTAL; Metabolism; Metabolomics; mTORC1; Nucleus Pulposus; Nucleus pulposus cells; Physiological aspects; China; Intervertebral disc degeneration; Lactic acid; mTORC1; Nucleus pulposus cells; Apoptosis

Lumbar disc herniation is a common disease characterized by the degeneration of intervertebral discs (IVDs), accompanied by imbalance of metabolic and inflammatory homeostasis. Current studies establish that IVD degeneration is induced by increased apoptosis of nucleus pulposus (NP) cells. However,...