Molecular analysis of the heavy chain variable region genes of human hybridoma clones specific for coagulation factor VIII

• Published in: Thrombosis and haemostasis Vol. 94; no. 6; p. 1131
• Main Authors: Gharagozlou, Soheila, Kardar, Gholam Ali, Rabbani, Hodjattallah, Shokri, Fazel
• Format: Journal Article
• Language: English
• Published: Germany 01.12.2005
• Subjects: Adult; Amino Acid Sequence; Antibodies, Monoclonal - chemistry; Antibodies, Monoclonal - genetics; Base Sequence; Cells, Cultured; Factor VIII - antagonists & inhibitors; Factor VIII - immunology; Factor VIII - therapeutic use; Hemophilia A - blood; Hemophilia A - drug therapy; Hemophilia A - immunology; Humans; Hybridomas; Immunoglobulin Heavy Chains - chemistry; Immunoglobulin Heavy Chains - genetics; Immunoglobulin Variable Region - chemistry; Immunoglobulin Variable Region - genetics; Middle Aged; Molecular Sequence Data; Protein Conformation; Sequence Alignment

HemophiliaA is a X-linked hematologic disorder characterized by undetectable or low amounts of functional coagulation factor VIII (FVIII). Replacement therapy induces FVIII neutralizing antibody (Ab) (inhibitor) in a proportion of patients which makes further treatment of these patients ineffective...