Antagonism of CRTH2 ameliorates chronic epicutaneous sensitization-induced inflammation by multiple mechanisms

• Published in: International immunology Vol. 21; no. 1; pp. 1 - 17
• Main Authors: Boehme, Stefen A., Chen, Edward P., Franz-Bacon, Karin, Šášik, Roman, Sprague, L. James, Ly, Tai Wei, Hardiman, Gary, Bacon, Kevin B.
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.01.2009; Oxford Publishing Limited (England)
• Subjects: allergy; Animals; Antigens, CD - drug effects; Antigens, CD - metabolism; CD4-Positive T-Lymphocytes - drug effects; CD4-Positive T-Lymphocytes - immunology; CD4-Positive T-Lymphocytes - metabolism; Cells, Cultured; CRTH2; Cytokines - analysis; Cytokines - drug effects; Cytokines - immunology; Dendritic Cells - drug effects; Dendritic Cells - immunology; Dendritic Cells - metabolism; Dermatitis, Atopic - chemically induced; Dermatitis, Atopic - immunology; Dermatitis, Atopic - pathology; Female; Gene Expression - drug effects; Gene Expression - immunology; Immunoglobulins - blood; Immunoglobulins - drug effects; inflammation; Mice; Mice, Inbred BALB C; Original Research Papers; Ovalbumin - immunology; Prostaglandin Antagonists - pharmacology; prostaglandin D2; Prostaglandin D2 - immunology; Prostaglandin D2 - metabolism; Receptors, Immunologic - antagonists & inhibitors; Receptors, Immunologic - metabolism; Receptors, Prostaglandin - antagonists & inhibitors; Receptors, Prostaglandin - metabolism; skin; Up-Regulation; skin; allergy; CRTH2; inflammation; prostaglandin D

Prostaglandin D2 (PGD2) and its receptor chemoattractant receptor homologous molecule expressed on Th2 cells (CRTH2) have been implicated in the pathogenesis of numerous allergic diseases. We investigated the role of PGD2 and CRTH2 in allergic cutaneous inflammation by using a highly potent and spec...