Are transient protein-protein interactions more dispensable?

• Published in: PLoS computational biology Vol. 18; no. 4; p. e1010013
• Main Authors: Ghadie, Mohamed Ali, Xia, Yu
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.04.2022; Public Library of Science (PLoS)
• Subjects: Bayes Theorem; Bayesian analysis; Biology and Life Sciences; Datasets; Evolution; Experiments; Gene expression; Humans; Interfaces; Mutation; Physical Sciences; Protein interaction; Protein Interaction Mapping - methods; Protein research; Protein-protein interactions; Proteins; Research and Analysis Methods; Signal transduction; Structural models; Three dimensional models; Canada

Protein-protein interactions (PPIs) are key drivers of cell function and evolution. While it is widely assumed that most permanent PPIs are important for cellular function, it remains unclear whether transient PPIs are equally important. Here, we estimate and compare dispensable content among transi...