In SARS-CoV-2 delta variants, Spike-P681R and D950N promote membrane fusion, Spike-P681R enhances spike cleavage, but neither substitution affects pathogenicity in hamsters - Furusawa, Yuri; Kiso, Maki; Iida, Shun; Uraki, Ryuta; Hirata, Yuichiro; Imai, Masaki; Suzuki, Tadaki; Yamayoshi, Seiya; Kawaoka, Yoshihiro (EBioMedicine, 2023)
Keywords: Advanced Basic Science; Animals; COVID-19; Cricetinae; Hamster; Internal Medicine; Membrane Fusion; Reverse genetics; SARS-CoV-2; Virulence - genetics; COVID-19; SARS-CoV-2; Hamster; Reverse genetics