Tbx1, a gene encoded in 22q11.2 copy number variant, is a link between alterations in fimbria myelination and cognitive speed in mice

• Published in: Molecular psychiatry Vol. 27; no. 2; pp. 929 - 938
• Main Authors: Hiramoto, Takeshi, Sumiyoshi, Akira, Yamauchi, Takahira, Tanigaki, Kenji, Shi, Qian, Kang, Gina, Ryoke, Rie, Nonaka, Hiroi, Enomoto, Shingo, Izumi, Takeshi, Bhat, Manzoor A., Kawashima, Ryuta, Hiroi, Noboru
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.02.2022; Nature Publishing Group
• Subjects: 101/28; 13; 59/57; 631/378; 64/60; 692/699/476/1373; Accuracy; Animal cognition; Animals; Axons; Behavioral Sciences; Biological Psychology; Brain; Chromosome 22; Chromosome deletion; Cognition; Cognitive ability; Cognitive development; Copy number; DNA Copy Number Variations - genetics; Fornix; Gene deletion; Genes; Glial stem cells; Health sciences; Heterozygote; Magnetic resonance imaging; Medicine; Medicine & Public Health; Memory; Mental disorders; Mice; mRNA; Myelination; Neuroimaging; Neurosciences; Oligodendrocytes; Oligodendroglia; Pharmacotherapy; Progenitor cells; Proteins; Psychiatry; Schizophrenia; Spatial memory; Stem cells; Subventricular zone; T-Box Domain Proteins - genetics; Tbx1 protein; Variance analysis

Copy number variants (CNVs) have provided a reliable entry point to identify the structural correlates of atypical cognitive development. Hemizygous deletion of human chromosome 22q11.2 is associated with impaired cognitive function; however, the mechanisms by which the CNVs contribute to cognitive...