Compartmentalized Replication of R5 T Cell-Tropic HIV-1 in the Central Nervous System Early in the Course of Infection

• Published in: PLoS pathogens Vol. 11; no. 3; p. e1004720
• Main Authors: Sturdevant, Christa Buckheit, Joseph, Sarah B., Schnell, Gretja, Price, Richard W., Swanstrom, Ronald, Spudich, Serena
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.03.2015; Public Library of Science (PLoS)
• Subjects: Acquired immune deficiency syndrome; Adult; AIDS; AIDS Dementia Complex - blood; AIDS Dementia Complex - cerebrospinal fluid; AIDS Dementia Complex - pathology; Cell Line; Central nervous system; Central Nervous System - metabolism; Central Nervous System - pathology; Central Nervous System - virology; Cloning; Female; Genetic aspects; Genotype & phenotype; Health aspects; HIV; HIV infections; HIV-1 - pathogenicity; HIV-1 - physiology; Host-virus relationships; Human immunodeficiency virus; Humans; Identification and classification; Infections; Lymphocytes; Male; Medical research; Middle Aged; Nervous system; Phylogenetics; Population; RNA, Viral - blood; RNA, Viral - cerebrospinal fluid; T cells; Viral Tropism; Virus Replication

Compartmentalized HIV-1 replication within the central nervous system (CNS) likely provides a foundation for neurocognitive impairment and a potentially important tissue reservoir. The timing of emergence and character of this local CNS replication has not been defined in a population of subjects. W...