A mathematical model of calcium dynamics: Obesity and mitochondria-associated ER membranes

• Published in: PLoS computational biology Vol. 15; no. 8; p. e1006661
• Main Authors: Han, Jung Min, Periwal, Vipul
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.08.2019; Public Library of Science (PLoS)
• Subjects: Adenosine triphosphate; Adenosine Triphosphate - metabolism; Analysis; Animals; Apposition; ATP; Biology and Life Sciences; Calcium; Calcium (intracellular); Calcium (Nutrient); Calcium ions; Calcium Signaling - physiology; Calcium signalling; Chemical kinetics; Computational Biology; Computer Simulation; Correlation analysis; Diabetes; Dynamics; Endoplasmic reticulum; Endoplasmic Reticulum - metabolism; Hepatocytes; Hepatocytes - metabolism; Homeostasis; Humans; Inositol Phosphates - metabolism; Insulin resistance; Intracellular; Investigations; Kidney diseases; Laboratories; Liver; Mathematical analysis; Mathematical Concepts; Mathematical models; Medicine and Health Sciences; Membranes; Metabolic disorders; Metabolic Networks and Pathways; Mice; Mitochondria; Mitochondria - metabolism; Mitochondria, Liver - metabolism; Mitochondrial membrane; Models, Biological; Obesity; Obesity - metabolism; Organelles; Research and Analysis Methods; Sarcoplasmic Reticulum Calcium-Transporting ATPases - metabolism; United States; United States > US; Maryland

Multiple cellular organelles tightly orchestrate intracellular calcium (Ca2+) dynamics to regulate cellular activities and maintain homeostasis. The interplay between the endoplasmic reticulum (ER), a major store of intracellular Ca2+, and mitochondria, an important source of adenosine triphosphate...