Antagonism of P2Y12 or GPIIb/IIIa receptors reduces platelet-mediated myocardial injury after ischaemia and reperfusion in isolated rat hearts

• Published in: Thrombosis and haemostasis Vol. 104; no. 1; p. 128
• Main Authors: Barrabés, José A, Inserte, Javier, Mirabet, Maribel, Quiroga, Adoración, Hernando, Victor, Figueras, Jaume, Garcia-Dorado, David
• Format: Journal Article
• Language: English
• Published: Germany 01.07.2010
• Subjects: Abciximab; Adenosine Monophosphate - analogs & derivatives; Adenosine Monophosphate - pharmacology; Animals; Antibodies, Monoclonal - pharmacology; Blood Platelets - drug effects; Blood Platelets - metabolism; Blood Platelets - pathology; Female; Humans; Immunoglobulin Fab Fragments - pharmacology; Male; Middle Aged; Myocardial Infarction - drug therapy; Myocardial Infarction - pathology; Myocardial Infarction - physiopathology; Myocardium - metabolism; Myocardium - pathology; P-Selectin - genetics; P-Selectin - metabolism; Platelet Activation - drug effects; Platelet Glycoprotein GPIIb-IIIa Complex - antagonists & inhibitors; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2 - metabolism; Reperfusion Injury; Ventricular Function, Left - drug effects

Platelets activated during experimental acute myocardial infarction (AMI) contribute to myocardial injury. This study aimed to investigate whether platelets from patients with AMI increase myocardial injury after ischaemia and reperfusion in isolated rat hearts and the modification of this effect by...