Red blood cell alloimmunization among transfusion-dependent thalassemia major patients in Northeastern Iran
Abstract BACKGROUND: Thalassemia is one of the most common congenital hemoglobinopathies globally. Regular red blood cell (RBC) transfusion is of paramount importance in the treatment of thalassemia patients. However, this practice increases the risk of alloimmunization. This study was performed to...
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| Published in | Asian journal of transfusion science Vol. 18; no. 2; pp. 214 - 218 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
India
Wolters Kluwer - Medknow
01.07.2024
Medknow Publications and Media Pvt. Ltd Medknow Publications & Media Pvt. Ltd Wolters Kluwer Medknow Publications |
| Edition | 2 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0973-6247 1998-3565 |
| DOI | 10.4103/ajts.ajts_107_21 |
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| Abstract | Abstract
BACKGROUND:
Thalassemia is one of the most common congenital hemoglobinopathies globally. Regular red blood cell (RBC) transfusion is of paramount importance in the treatment of thalassemia patients. However, this practice increases the risk of alloimmunization. This study was performed to determine the prevalence of RBC antibodies among multiple-transfused thalassemic patients in southern Khorasan, the eastern side of Iran.
METHODS:
For the purpose of screening unexpected antibodies, blood samples of 68 β-thalassemia major patients were investigated. After determining positive cases through screening phase, the process of antibody identification was carried out using reagent cells.
RESULTS:
The overall rate of alloimmunization was 2.9%, and the most frequent clinically important alloantibodies were anti-Kell and anti-Rh systems. Anti-K was detected in one of the patients. Furthermore, the simultaneous occurrence of anti-E and anti-C was seen in another study subject.
CONCLUSION:
A number of factors might have contributed to the low alloimmunization rate detected in this study, including the homogeneity of the population in South Khorasan, well-matched donors for those patients, first transfusion at an early age, and the use of leukodepleted blood. |
|---|---|
| AbstractList | Abstract
BACKGROUND:
Thalassemia is one of the most common congenital hemoglobinopathies globally. Regular red blood cell (RBC) transfusion is of paramount importance in the treatment of thalassemia patients. However, this practice increases the risk of alloimmunization. This study was performed to determine the prevalence of RBC antibodies among multiple-transfused thalassemic patients in southern Khorasan, the eastern side of Iran.
METHODS:
For the purpose of screening unexpected antibodies, blood samples of 68 β-thalassemia major patients were investigated. After determining positive cases through screening phase, the process of antibody identification was carried out using reagent cells.
RESULTS:
The overall rate of alloimmunization was 2.9%, and the most frequent clinically important alloantibodies were anti-Kell and anti-Rh systems. Anti-K was detected in one of the patients. Furthermore, the simultaneous occurrence of anti-E and anti-C was seen in another study subject.
CONCLUSION:
A number of factors might have contributed to the low alloimmunization rate detected in this study, including the homogeneity of the population in South Khorasan, well-matched donors for those patients, first transfusion at an early age, and the use of leukodepleted blood. Thalassemia is one of the most common congenital hemoglobinopathies globally. Regular red blood cell (RBC) transfusion is of paramount importance in the treatment of thalassemia patients. However, this practice increases the risk of alloimmunization. This study was performed to determine the prevalence of RBC antibodies among multiple-transfused thalassemic patients in southern Khorasan, the eastern side of Iran. For the purpose of screening unexpected antibodies, blood samples of 68 β-thalassemia major patients were investigated. After determining positive cases through screening phase, the process of antibody identification was carried out using reagent cells. The overall rate of alloimmunization was 2.9%, and the most frequent clinically important alloantibodies were anti-Kell and anti-Rh systems. Anti-K was detected in one of the patients. Furthermore, the simultaneous occurrence of anti-E and anti-C was seen in another study subject. A number of factors might have contributed to the low alloimmunization rate detected in this study, including the homogeneity of the population in South Khorasan, well-matched donors for those patients, first transfusion at an early age, and the use of leukodepleted blood. Thalassemia is one of the most common congenital hemoglobinopathies globally. Regular red blood cell (RBC) transfusion is of paramount importance in the treatment of thalassemia patients. However, this practice increases the risk of alloimmunization. This study was performed to determine the prevalence of RBC antibodies among multiple-transfused thalassemic patients in southern Khorasan, the eastern side of Iran. For the purpose of screening unexpected antibodies, blood samples of 68 β-thalassemia major patients were investigated. After determining positive cases through screening phase, the process of antibody identification was carried out using reagent cells. The overall rate of alloimmunization was 2.9, and the most frequent clinically important alloantibodies were anti-Kell and anti-Rh systems. Anti-K was detected in one of the patients. Furthermore, the simultaneous occurrence of anti-E and anti-C was seen in another study subject. A number of factors might have contributed to the low alloimmunization rate detected in this study, including the homogeneity of the population in South Khorasan, well-matched donors for those patients, first transfusion at an early age, and the use of leukodepleted blood. AbstractBACKGROUND:Thalassemia is one of the most common congenital hemoglobinopathies globally. Regular red blood cell (RBC) transfusion is of paramount importance in the treatment of thalassemia patients. However, this practice increases the risk of alloimmunization. This study was performed to determine the prevalence of RBC antibodies among multiple-transfused thalassemic patients in southern Khorasan, the eastern side of Iran.METHODS:For the purpose of screening unexpected antibodies, blood samples of 68 β-thalassemia major patients were investigated. After determining positive cases through screening phase, the process of antibody identification was carried out using reagent cells.RESULTS:The overall rate of alloimmunization was 2.9%, and the most frequent clinically important alloantibodies were anti-Kell and anti-Rh systems. Anti-K was detected in one of the patients. Furthermore, the simultaneous occurrence of anti-E and anti-C was seen in another study subject.CONCLUSION:A number of factors might have contributed to the low alloimmunization rate detected in this study, including the homogeneity of the population in South Khorasan, well-matched donors for those patients, first transfusion at an early age, and the use of leukodepleted blood. BACKGROUND: Thalassemia is one of the most common congenital hemoglobinopathies globally. Regular red blood cell (RBC) transfusion is of paramount importance in the treatment of thalassemia patients. However, this practice increases the risk of alloimmunization. This study was performed to determine the prevalence of RBC antibodies among multiple-transfused thalassemic patients in southern Khorasan, the eastern side of Iran. METHODS: For the purpose of screening unexpected antibodies, blood samples of 68 β-thalassemia major patients were investigated. After determining positive cases through screening phase, the process of antibody identification was carried out using reagent cells. RESULTS: The overall rate of alloimmunization was 2.9%, and the most frequent clinically important alloantibodies were anti-Kell and anti-Rh systems. Anti-K was detected in one of the patients. Furthermore, the simultaneous occurrence of anti-E and anti-C was seen in another study subject. CONCLUSION: A number of factors might have contributed to the low alloimmunization rate detected in this study, including the homogeneity of the population in South Khorasan, well-matched donors for those patients, first transfusion at an early age, and the use of leukodepleted blood. Thalassemia is one of the most common congenital hemoglobinopathies globally. Regular red blood cell (RBC) transfusion is of paramount importance in the treatment of thalassemia patients. However, this practice increases the risk of alloimmunization. This study was performed to determine the prevalence of RBC antibodies among multiple-transfused thalassemic patients in southern Khorasan, the eastern side of Iran.BACKGROUNDThalassemia is one of the most common congenital hemoglobinopathies globally. Regular red blood cell (RBC) transfusion is of paramount importance in the treatment of thalassemia patients. However, this practice increases the risk of alloimmunization. This study was performed to determine the prevalence of RBC antibodies among multiple-transfused thalassemic patients in southern Khorasan, the eastern side of Iran.For the purpose of screening unexpected antibodies, blood samples of 68 β-thalassemia major patients were investigated. After determining positive cases through screening phase, the process of antibody identification was carried out using reagent cells.METHODSFor the purpose of screening unexpected antibodies, blood samples of 68 β-thalassemia major patients were investigated. After determining positive cases through screening phase, the process of antibody identification was carried out using reagent cells.The overall rate of alloimmunization was 2.9%, and the most frequent clinically important alloantibodies were anti-Kell and anti-Rh systems. Anti-K was detected in one of the patients. Furthermore, the simultaneous occurrence of anti-E and anti-C was seen in another study subject.RESULTSThe overall rate of alloimmunization was 2.9%, and the most frequent clinically important alloantibodies were anti-Kell and anti-Rh systems. Anti-K was detected in one of the patients. Furthermore, the simultaneous occurrence of anti-E and anti-C was seen in another study subject.A number of factors might have contributed to the low alloimmunization rate detected in this study, including the homogeneity of the population in South Khorasan, well-matched donors for those patients, first transfusion at an early age, and the use of leukodepleted blood.CONCLUSIONA number of factors might have contributed to the low alloimmunization rate detected in this study, including the homogeneity of the population in South Khorasan, well-matched donors for those patients, first transfusion at an early age, and the use of leukodepleted blood. BACKGROUND: Thalassemia is one of the most common congenital hemoglobinopathies globally. Regular red blood cell (RBC) transfusion is of paramount importance in the treatment of thalassemia patients. However, this practice increases the risk of alloimmunization. This study was performed to determine the prevalence of RBC antibodies among multiple-transfused thalassemic patients in southern Khorasan, the eastern side of Iran. METHODS: For the purpose of screening unexpected antibodies, blood samples of 68 β-thalassemia major patients were investigated. After determining positive cases through screening phase, the process of antibody identification was carried out using reagent cells. RESULTS: The overall rate of alloimmunization was 2.9, and the most frequent clinically important alloantibodies were anti-Kell and anti-Rh systems. Anti-K was detected in one of the patients. Furthermore, the simultaneous occurrence of anti-E and anti-C was seen in another study subject. CONCLUSION: A number of factors might have contributed to the low alloimmunization rate detected in this study, including the homogeneity of the population in South Khorasan, well-matched donors for those patients, first transfusion at an early age, and the use of leukodepleted blood. Keywords: Alloantibody screening, alloimmunization, β-thalassemia major |
| Audience | Academic |
| Author | Mobasheri, Leila Chahkandi, Tayyebeh Talebpour, Amir Sarab, Gholamreza Anani |
| AuthorAffiliation | 1 Department of Pediatrics, Birjand University of Medical Sciences, Birjand, Iran 2 Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran Department of Childhealth, Birjand University of Medical Sciences, Birjand, Iran |
| AuthorAffiliation_xml | – name: 1 Department of Pediatrics, Birjand University of Medical Sciences, Birjand, Iran – name: 2 Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran – name: Department of Childhealth, Birjand University of Medical Sciences, Birjand, Iran |
| Author_xml | – sequence: 1 givenname: Leila surname: Mobasheri fullname: Mobasheri, Leila – sequence: 2 givenname: Tayyebeh surname: Chahkandi fullname: Chahkandi, Tayyebeh – sequence: 3 givenname: Amir surname: Talebpour fullname: Talebpour, Amir – sequence: 4 givenname: Gholamreza Anani surname: Sarab fullname: Sarab, Gholamreza Anani email: ghansa@yahoo.com |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/39822688$$D View this record in MEDLINE/PubMed |
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BACKGROUND:
Thalassemia is one of the most common congenital hemoglobinopathies globally. Regular red blood cell (RBC) transfusion is of paramount... Thalassemia is one of the most common congenital hemoglobinopathies globally. Regular red blood cell (RBC) transfusion is of paramount importance in the... BACKGROUND: Thalassemia is one of the most common congenital hemoglobinopathies globally. Regular red blood cell (RBC) transfusion is of paramount importance... AbstractBACKGROUND:Thalassemia is one of the most common congenital hemoglobinopathies globally. Regular red blood cell (RBC) transfusion is of paramount... |
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| SubjectTerms | alloantibody screening alloimmunization Antibodies Blood Blood diseases Blood transfusion Care and treatment Ethylenediaminetetraacetic acid Genetic disorders Medical research Medicine, Experimental Original Original Article Thalassemia Viral antibodies β-thalassemia major |
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| Title | Red blood cell alloimmunization among transfusion-dependent thalassemia major patients in Northeastern Iran |
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