Safety and immunogenicity of a live attenuated influenza H5 candidate vaccine strain A/17/turkey/Turkey/05/133 H5N2 and its priming effects for potential pre-pandemic use: a randomised, double-blind, placebo-controlled trial

• Published in: The Lancet infectious diseases Vol. 17; no. 8; pp. 833 - 842
• Main Authors: Pitisuttithum, Punnee, Boonnak, Kobporn, Chamnanchanunt, Supat, Puthavathana, Pilaipan, Luvira, Viravarn, Lerdsamran, Hatairat, Kaewkungwal, Jaranit, Lawpoolsri, Saranath, Thanachartwet, Vipa, Silachamroon, Udomsak, Masamae, Wanibtisam, Schuetz, Alexandra, Wirachwong, Ponthip, Thirapakpoomanunt, Sit, Rudenko, Larisa, Sparrow, Erin, Friede, Martin, Kieny, Marie-Paule
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 01.08.2017; Elsevier Limited; Elsevier Science ;, The Lancet Pub. Group
• Subjects: Administration, Intranasal; Adolescent; Adult; Adults; Adverse events; Animals; Antibodies; Antibodies, Neutralizing - blood; Antibodies, Viral - blood; Avian flu; Clinical trials; Deactivation; Double-Blind Method; Double-blind studies; Drug dosages; Drug-Related Side Effects and Adverse Reactions - epidemiology; Drug-Related Side Effects and Adverse Reactions - pathology; Epidemics; Female; Healthy Volunteers; Helper cells; Hemagglutination; Hemagglutination inhibition; Hemagglutination Inhibition Tests; Humans; Immune response; Immunization; Immunogenicity; Immunological memory; Infectious Disease; Infectious diseases; Influenza; Influenza A Virus, H5N1 Subtype - immunology; Influenza A Virus, H5N2 Subtype - immunology; Influenza Vaccines - administration & dosage; Influenza Vaccines - adverse effects; Influenza Vaccines - immunology; Influenza, Human - prevention & control; Injections, Intramuscular; Long term memory; Male; Middle Aged; Neutralization Tests; Pandemics; Placebos; Placebos - administration & dosage; Plasma Cells - immunology; Priming; Randomization; Safety; T-Lymphocytes - immunology; Thailand; Vaccination; Vaccines; Vaccines, Attenuated - administration & dosage; Vaccines, Attenuated - adverse effects; Vaccines, Attenuated - immunology; Viruses; Women; Workers; Young Adult; Thailand; Turkey; Hong Kong China; Vietnam; China; Russia

The emergence of highly pathogenic avian influenza H5N1 viruses has raised concerns about their pandemic potential. Vaccination is the most effective way of preventing influenza. In this study, we investigated the safety and immunogenicity of an avian H5N2 live attenuated influenza vaccine (LAIV H5N...