Safety and immunogenicity of a live attenuated influenza H5 candidate vaccine strain A/17/turkey/Turkey/05/133 H5N2 and its priming effects for potential pre-pandemic use: a randomised, double-blind, placebo-controlled trial - Pitisuttithum, Punnee; Boonnak, Kobporn; Chamnanchanunt, Supat; Puthavathana, Pilaipan; Luvira, Viravarn; Lerdsamran, Hatairat; Kaewkungwal, Jaranit; Lawpoolsri, Saranath; Thanachartwet, Vipa; Silachamroon, Udomsak; Masamae, Wanibtisam; Schuetz, Alexandra; et al. (The Lancet infectious diseases, 2017)
Keywords: Administration, Intranasal; Adolescent; Adult; Adults; Adverse events; Animals; Antibodies; Antibodies, Neutralizing - blood; Antibodies, Viral - blood; Avian flu; Clinical trials; Deactivation; Double-Blind Method; Double-blind studies; Drug dosages; Drug-Related Side Effects and Adverse Reactions - epidemiology; Drug-Related Side Effects and Adverse Reactions - pathology; Epidemics; Female; Healthy Volunteers; Helper cells; Hemagglutination; Hemagglutination inhibition; Hemagglutination Inhibition Tests; Humans; Immune response; Immunization; Immunogenicity; Immunological memory; Infectious Disease; Infectious diseases; Influenza; Influenza A Virus, H5N1 Subtype - immunology; Influenza A Virus, H5N2 Subtype - immunology; Influenza Vaccines - administration & dosage; Influenza Vaccines - adverse effects; Influenza Vaccines - immunology; Influenza, Human - prevention & control; Injections, Intramuscular; Long term memory; Male; Middle Aged; Neutralization Tests; Pandemics; Placebos; Placebos - administration & dosage; Plasma Cells - immunology; Priming; Randomization; Safety; T-Lymphocytes - immunology; Thailand; Vaccination; Vaccines; Vaccines, Attenuated - administration & dosage; Vaccines, Attenuated - adverse effects; Vaccines, Attenuated - immunology; Viruses; Women; Workers; Young Adult; Thailand; Turkey; Hong Kong China; Vietnam; China; Russia