Thrombospondin-2 and extracellular matrix assembly

• Published in: Biochimica et biophysica acta Vol. 1840; no. 8; pp. 2396 - 2402
• Main Authors: Calabro, Nicole E., Kristofik, Nina J., Kyriakides, Themis R.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.08.2014
• Subjects: Angiogenesis; Animals; Collagen; Collagen - metabolism; Decellularization; Disease Models, Animal; elastin; Extracellular matrix; Extracellular Matrix - metabolism; Extracellular Matrix - ultrastructure; fibronectins; Humans; in vitro studies; metalloproteinases; mice; Phenotype; proteoglycans; Thrombospondin; Thrombospondins - deficiency; Thrombospondins - metabolism; Tissue Engineering; tissue repair; Angiogenesis; Extracellular matrix; Collagen; Decellularization; Thrombospondin

Numerous proteins and small leucine-rich proteoglycans (SLRPs) make up the composition of the extracellular matrix (ECM). Assembly of individual fibrillar components in the ECM, such as collagen, elastin, and fibronectin, is understood at the molecular level. In contrast, the incorporation of non-fi...