Metagenomic analysis of the lung microbiome in pulmonary tuberculosis - a pilot study

• Published in: Emerging microbes & infections Vol. 9; no. 1; pp. 1444 - 1452
• Main Authors: Hu, Yongfeng, Cheng, Min, Liu, Bo, Dong, Jie, Sun, Lilian, Yang, Jian, Yang, Fan, Chen, Xinchun, Jin, Qi
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 01.01.2020; Taylor & Francis Ltd; Taylor & Francis Group
• Subjects: 16S rDNA; Bacteria - classification; Bacteria - genetics; Bacteria - isolation & purification; bronchoalveolar lavage; Bronchoalveolar Lavage Fluid - microbiology; Humans; Lung - microbiology; Lung microbiome; Metagenome; metagenomic analysis; Metagenomics; Microbiota; Mycobacterium tuberculosis - genetics; Mycobacterium tuberculosis - physiology; Pilot Projects; Tuberculosis; Tuberculosis, Pulmonary - diagnosis; Tuberculosis, Pulmonary - microbiology; metagenomic analysis; 16S rDNA; Lung microbiome; bronchoalveolar lavage; tuberculosis

The lung microbiome plays an important role in the pathophysiological processes associated with pulmonary tuberculosis (PTB). However, only a few studies using 16S rDNA amplicon sequencing have been reported, and the interactions between Mycobacterium tuberculosis (MTB) and the lung microbiome remai...