DTI-based connectome analysis of adolescents with major depressive disorder reveals hypoconnectivity of the right caudate

• Published in: Journal of affective disorders Vol. 207; pp. 18 - 25
• Main Authors: Tymofiyeva, Olga, Connolly, Colm G., Ho, Tiffany C., Sacchet, Matthew D., Henje Blom, Eva, LeWinn, Kaja Z., Xu, Duan, Yang, Tony T.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.01.2017
• Subjects: Adolescence; Adolescent; Anisotropy; Brain; Brain - diagnostic imaging; Brain - physiopathology; Caudate; Caudate Nucleus - diagnostic imaging; Caudate Nucleus - physiopathology; Connectome; Connectomics; Depression; Depressive Disorder, Major - diagnostic imaging; Depressive Disorder, Major - physiopathology; Diffusion; Diffusion Tensor Imaging; Female; Frontal Lobe - diagnostic imaging; Frontal Lobe - physiopathology; Graph theory; Gyrus Cinguli - diagnostic imaging; Gyrus Cinguli - physiopathology; Humans; Life Change Events; Male; MRI; Neural network; Prefrontal Cortex - diagnostic imaging; Prefrontal Cortex - physiopathology; Psychiatric/Mental Health; Research Design; Self Report; Stress, Psychological - diagnostic imaging; Stress, Psychological - physiopathology; Tractography; Adolescence; Brain; Caudate; MRI; Tractography; Depression; Graph theory; Neural network; Diffusion; Connectomics

Adolescence is a vulnerable period for the onset of major depressive disorder (MDD). While some studies have shown white matter alterations in adolescent MDD, there is still a gap in understanding how the brain is affected at a network level. We compared diffusion tensor imaging (DTI)-based brain ne...