Sexually Dimorphic Changes of Hypocretin (Orexin) in Depression

• Published in: EBioMedicine Vol. 18; no. C; pp. 311 - 319
• Main Authors: Lu, Jing, Zhao, Juan, Balesar, Rawien, Fronczek, Rolf, Zhu, Qiong-Bin, Wu, Xue-Yan, Hu, Shao-Hua, Bao, Ai-Min, Swaab, Dick F.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.04.2017; Elsevier
• Subjects: Advanced Basic Science; Aged; Aged, 80 and over; Animals; Bipolar Disorder - metabolism; Bipolar Disorder - pathology; Corticosterone - blood; Corticotropin-Releasing Hormone - genetics; Corticotropin-Releasing Hormone - metabolism; Depression; Depressive Disorder, Major - metabolism; Depressive Disorder, Major - pathology; Disease Models, Animal; Female; Gyrus Cinguli - metabolism; Humans; Hypocretin; Hypocretin receptors; Hypothalamus; Hypothalamus - metabolism; Immunohistochemistry; Internal Medicine; Male; Middle Aged; Orexin Receptors - genetics; Orexin Receptors - metabolism; Orexins - genetics; Orexins - metabolism; Prefrontal Cortex - metabolism; Protein Precursors - metabolism; Rats; Rats, Sprague-Dawley; Research Paper; RNA, Messenger - metabolism; Sex Characteristics; Sex difference; Depression; Hypothalamus; Hypocretin receptors; Sex difference; Hypocretin

Neurophysiological and behavioral processes regulated by hypocretin (orexin) are severely affected in depression. However, alterations in hypocretin have so far not been studied in the human brain. We explored the hypocretin system changes in the hypothalamus and cortex in depression from male and f...