Forward and reverse translational approaches to predict efficacy of neutralizing respiratory syncytial virus (RSV) antibody prophylaxis

• Published in: EBioMedicine Vol. 73; p. 103651
• Main Authors: Maas, Brian M., Lommerse, Jos, Plock, Nele, Railkar, Radha A., Cheung, S.Y. Amy, Caro, Luzelena, Chen, Jingxian, Liu, Wen, Zhang, Ying, Huang, Qinlei, Gao, Wei, Qin, Li, Meng, Jie, Witjes, Han, Schindler, Emilie, Guiastrennec, Benjamin, Bellanti, Francesco, Spellman, Daniel S., Roadcap, Brad, Kalinova, Mariya, Fok-Seang, Juin, Catchpole, Andrew P., Espeseth, Amy S., Stoch, S. Aubrey, Lai, Eseng, Vora, Kalpit A., Aliprantis, Antonios O., Sachs, Jeffrey R.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.11.2021; Elsevier
• Subjects: Adolescent; Adult; Advanced Basic Science; Aged; Algorithms; Antibodies, Monoclonal; Antibodies, Neutralizing - administration & dosage; Antibodies, Neutralizing - immunology; Antibodies, Viral - administration & dosage; Antibodies, Viral - immunology; Clinical Trials as Topic; Female; Human Challenge Study; Humans; Incidence; Internal Medicine; Male; Middle Aged; Modelling and Simulation; Models, Theoretical; Monoclonal Antibody; Premedication; Research paper; Respiratory Syncytial Virus; Respiratory Syncytial Virus Infections - epidemiology; Respiratory Syncytial Virus Infections - immunology; Respiratory Syncytial Virus Infections - prevention & control; Respiratory Syncytial Virus, Human - immunology; RSV, Meta-analysis; Seasons; Translational Research, Biomedical - methods; Young Adult; RSV, Meta-analysis; Modelling and Simulation; Human Challenge Study; Respiratory Syncytial Virus; Monoclonal Antibody

Neutralizing mAbs can prevent communicable viral diseases. MK-1654 is a respiratory syncytial virus (RSV) F glycoprotein neutralizing monoclonal antibody (mAb) under development to prevent RSV infection in infants. Development and validation of methods to predict efficacious doses of neutralizing an...