Focal Adhesion Kinase Is a Substrate and Downstream Effector of SHP-2 Complexed with Helicobacter pylori CagA

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Published inMolecular and Cellular Biology Vol. 26; no. 1; pp. 261 - 276
Main Authors Tsutsumi, Ryouhei, Takahashi, Atsushi, Azuma, Takeshi, Higashi, Hideaki, Hatakeyama, Masanori
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 01.01.2006
Taylor & Francis
Subjects
Antigens, Bacterial - metabolism
Bacterial Proteins - metabolism
Cell Membrane - enzymology
Cells, Cultured
Focal Adhesion Protein-Tyrosine Kinases - analysis
Focal Adhesion Protein-Tyrosine Kinases - antagonists & inhibitors
Focal Adhesion Protein-Tyrosine Kinases - metabolism
Gastric Mucosa - enzymology
Gastric Mucosa - microbiology
Gastric Mucosa - pathology
Helicobacter Infections - enzymology
Helicobacter pylori
Helicobacter pylori - pathogenicity
Humans
Intracellular Signaling Peptides and Proteins - metabolism
Phenotype
Phosphorylation
Phosphotransferases - metabolism
Protein Interaction Mapping
Protein Tyrosine Phosphatase, Non-Receptor Type 11
Protein Tyrosine Phosphatases - metabolism
Protein-Tyrosine Kinases
Proto-Oncogene Proteins - metabolism
src-Family Kinases
Online AccessGet full text
ISSN0270-7306
1098-5549
1098-5549
DOI10.1128/MCB.26.1.261-276.2006

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Abstract Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue MCB About MCB Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy MCB RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0270-7306 Online ISSN: 1098-5549 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to MCB .asm.org, visit: MCB       
AbstractList Infection with cagA-positive Helicobacter pylori (H. pylori) is associated with atrophic gastritis, peptic ulcer, and gastric adenocarcinoma. The cagA gene product CagA is translocated from H. pylori into gastric epithelial cells and undergoes tyrosine phosphorylation by Src family kinases (SFKs). Tyrosine-phosphorylated CagA binds and activates SHP-2 phosphatase and the C-terminal Src kinase (Csk) while inducing an elongated cell shape termed the "hummingbird phenotype." Here we show that CagA reduces the level of focal adhesion kinase (FAK) tyrosine phosphorylation in gastric epithelial cells. The decrease in phosphorylated FAK is due to SHP-2-mediated dephosphorylation of FAK at the activating phosphorylation sites, not due to Csk-dependent inhibition of SFKs, which phosphorylate FAK. Coexpression of constitutively active FAK with CagA inhibits induction of the hummingbird phenotype, whereas expression of dominant-negative FAK elicits an elongated cell shape characteristic of the hummingbird phenotype. These results indicate that inhibition of FAK by SHP-2 plays a crucial role in the morphogenetic activity of CagA. Impaired cell adhesion and increased motility by CagA may be involved in the development of gastric lesions associated with cagA-positive H. pylori infection.Infection with cagA-positive Helicobacter pylori (H. pylori) is associated with atrophic gastritis, peptic ulcer, and gastric adenocarcinoma. The cagA gene product CagA is translocated from H. pylori into gastric epithelial cells and undergoes tyrosine phosphorylation by Src family kinases (SFKs). Tyrosine-phosphorylated CagA binds and activates SHP-2 phosphatase and the C-terminal Src kinase (Csk) while inducing an elongated cell shape termed the "hummingbird phenotype." Here we show that CagA reduces the level of focal adhesion kinase (FAK) tyrosine phosphorylation in gastric epithelial cells. The decrease in phosphorylated FAK is due to SHP-2-mediated dephosphorylation of FAK at the activating phosphorylation sites, not due to Csk-dependent inhibition of SFKs, which phosphorylate FAK. Coexpression of constitutively active FAK with CagA inhibits induction of the hummingbird phenotype, whereas expression of dominant-negative FAK elicits an elongated cell shape characteristic of the hummingbird phenotype. These results indicate that inhibition of FAK by SHP-2 plays a crucial role in the morphogenetic activity of CagA. Impaired cell adhesion and increased motility by CagA may be involved in the development of gastric lesions associated with cagA-positive H. pylori infection.
Infection with cagA-positive Helicobacter pylori (H. pylori) is associated with atrophic gastritis, peptic ulcer, and gastric adenocarcinoma. The cagA gene product CagA is translocated from H. pylori into gastric epithelial cells and undergoes tyrosine phosphorylation by Src family kinases (SFKs). Tyrosine-phosphorylated CagA binds and activates SHP-2 phosphatase and the C-terminal Src kinase (Csk) while inducing an elongated cell shape termed the "hummingbird phenotype." Here we show that CagA reduces the level of focal adhesion kinase (FAK) tyrosine phosphorylation in gastric epithelial cells. The decrease in phosphorylated FAK is due to SHP-2-mediated dephosphorylation of FAK at the activating phosphorylation sites, not due to Csk-dependent inhibition of SFKs, which phosphorylate FAK. Coexpression of constitutively active FAK with CagA inhibits induction of the hummingbird phenotype, whereas expression of dominant-negative FAK elicits an elongated cell shape characteristic of the hummingbird phenotype. These results indicate that inhibition of FAK by SHP-2 plays a crucial role in the morphogenetic activity of CagA. Impaired cell adhesion and increased motility by CagA may be involved in the development of gastric lesions associated with cagA-positive H. pylori infection.
Infection with cagA -positive Helicobacter pylori ( H. pylori ) is associated with atrophic gastritis, peptic ulcer, and gastric adenocarcinoma. The cagA gene product CagA is translocated from H. pylori into gastric epithelial cells and undergoes tyrosine phosphorylation by Src family kinases (SFKs). Tyrosine-phosphorylated CagA binds and activates SHP-2 phosphatase and the C-terminal Src kinase (Csk) while inducing an elongated cell shape termed the “hummingbird phenotype.” Here we show that CagA reduces the level of focal adhesion kinase (FAK) tyrosine phosphorylation in gastric epithelial cells. The decrease in phosphorylated FAK is due to SHP-2-mediated dephosphorylation of FAK at the activating phosphorylation sites, not due to Csk-dependent inhibition of SFKs, which phosphorylate FAK. Coexpression of constitutively active FAK with CagA inhibits induction of the hummingbird phenotype, whereas expression of dominant-negative FAK elicits an elongated cell shape characteristic of the hummingbird phenotype. These results indicate that inhibition of FAK by SHP-2 plays a crucial role in the morphogenetic activity of CagA. Impaired cell adhesion and increased motility by CagA may be involved in the development of gastric lesions associated with cagA -positive H. pylori infection.
Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue MCB About MCB Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy MCB RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0270-7306 Online ISSN: 1098-5549 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to MCB .asm.org, visit: MCB       
Author Ryouhei Tsutsumi
Takeshi Azuma
Masanori Hatakeyama
Hideaki Higashi
Atsushi Takahashi
AuthorAffiliation Division of Molecular Oncology, Institute for Genetic Medicine and Division of Chemistry, Graduate School of Science, Hokkaido University, Sapporo, 1 International Center for Medical Research and Treatment, School of Medicine, Kobe University, Kobe, Japan 2
AuthorAffiliation_xml – name: Division of Molecular Oncology, Institute for Genetic Medicine and Division of Chemistry, Graduate School of Science, Hokkaido University, Sapporo, 1 International Center for Medical Research and Treatment, School of Medicine, Kobe University, Kobe, Japan 2
Author_xml – sequence: 1
  givenname: Ryouhei
  surname: Tsutsumi
  fullname: Tsutsumi, Ryouhei
  organization: Division of Molecular Oncology, Institute for Genetic Medicine and Division of Chemistry, Graduate School of Science, Hokkaido University
– sequence: 2
  givenname: Atsushi
  surname: Takahashi
  fullname: Takahashi, Atsushi
  organization: Division of Molecular Oncology, Institute for Genetic Medicine and Division of Chemistry, Graduate School of Science, Hokkaido University
– sequence: 3
  givenname: Takeshi
  surname: Azuma
  fullname: Azuma, Takeshi
  organization: International Center for Medical Research and Treatment, School of Medicine, Kobe University
– sequence: 4
  givenname: Hideaki
  surname: Higashi
  fullname: Higashi, Hideaki
  organization: Division of Molecular Oncology, Institute for Genetic Medicine and Division of Chemistry, Graduate School of Science, Hokkaido University
– sequence: 5
  givenname: Masanori
  surname: Hatakeyama
  fullname: Hatakeyama, Masanori
  email: mhata@igm.hokudai.ac.jp
  organization: Division of Molecular Oncology, Institute for Genetic Medicine and Division of Chemistry, Graduate School of Science, Hokkaido University
BackLink https://www.ncbi.nlm.nih.gov/pubmed/16354697$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1038/nature01082
10.1016/S0960-9822(03)00544-X
10.1038/351069a0
10.1074/jbc.M210670200
10.1006/bbrc.1996.1714
10.1128/MCB.24.12.5340-5352.2004
10.1046/j.1462-5822.2000.00043.x
10.1128/MCB.21.12.4016-4031.2001
10.1126/science.1067147
10.1084/jem.191.4.593
10.1073/pnas.222375399
10.1046/j.1365-2958.2002.02781.x
10.1002/jcp.10054
10.1074/jbc.M309964200
10.1073/pnas.90.12.5791
10.1242/jcs.00373
10.1016/S0021-9258(18)54220-4
10.1083/jcb.200312013
10.1128/MCB.19.4.3205
10.1016/S1097-2765(02)00681-0
10.1046/j.1365-2036.1999.00546.x
10.1073/pnas.97.3.1263
10.1016/S0021-9258(19)30019-5
10.1074/jbc.273.21.13223
10.1128/MCB.15.2.954
10.1002/(SICI)1097-0142(19990615)85:12<2506::AID-CNCR3>3.0.CO;2-I
10.1128/MCB.14.3.1680
10.1016/j.bbamcr.2004.04.008
10.1083/jcb.200208039
10.1056/NEJMoa001999
10.1128/MCB.19.4.3125
10.1038/nrc1433
10.1016/S0016-5085(98)70422-6
10.1111/j.1349-7006.2004.tb03229.x
10.1056/NEJM198912073212302
10.1074/jbc.C100754200
10.1073/pnas.96.25.14559
10.1093/emboj/cdg050
10.1126/science.287.5457.1497
10.1074/jbc.M208155200
10.1042/bj20020065
10.1074/jbc.273.33.21125
10.1016/S0955-0674(02)00368-X
10.1128/JCM.36.8.2258-2263.1998
10.1001/jama.1994.03520010077036
10.1046/j.1365-2958.2001.02649.x
10.1038/377539a0
10.1016/S1097-2765(04)00050-4
10.1074/jbc.270.29.17437
10.1074/jbc.M312575200
10.1017/S0950268899003209
10.1136/gut.40.3.297
10.1126/science.1081919
10.1006/excr.1999.4668
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Corresponding author. Mailing address: Division of Molecular Oncology, Institute for Genetic Medicine, Hokkaido University, Kita-15, Nishi-7, Kita-ku, Sapporo 060-0815, Japan. Phone and fax: 81-11-706-7544. E-mail: mhata@igm.hokudai.ac.jp.
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References Peng Z. Y. (R40) 1995; 11
Neel B. G. (R31) 2003; 28
Gabarra-Niecko V. (R17) 2002; 365
R21
R20
R23
R25
R24
R27
R26
R29
R28
Calalb M. B. (R9) 1996; 228
R1
R2
R3
R4
R5
R6
R8
Blaser M. J. (R7) 1995; 55
Higuchi M. (R22) 2004; 95
R30
R32
R34
R36
R35
R38
R37
Selbach M. (R47) 2003; 22
R39
Noguchi T. (R33) 1994; 14
Tsuda M. (R50) 1998; 273
R41
R43
R42
R45
R44
R46
R49
R48
R52
R51
R10
R54
R53
R12
R56
R11
R55
R14
R58
R13
R57
R16
R15
R18
R19
12719469 - J Cell Biol. 2003 Apr 28;161(2):249-55
14967142 - Mol Cell. 2004 Feb 13;13(3):341-55
2480346 - J Biol Chem. 1989 Dec 15;264(35):20886-93
14963045 - J Biol Chem. 2004 Apr 23;279(17):17205-16
12582165 - J Biol Chem. 2003 Apr 18;278(16):13952-8
11556297 - N Engl J Med. 2001 Sep 13;345(11):784-9
8516329 - Proc Natl Acad Sci U S A. 1993 Jun 15;90(12):5791-5
10082579 - Mol Cell Biol. 1999 Apr;19(4):3125-35
10688800 - Science. 2000 Feb 25;287(5457):1497-500
7478513 - Oncogene. 1995 Nov 16;11(10):1955-62
15263022 - J Cell Biol. 2004 Jul 19;166(2):283-95
15169898 - Mol Cell Biol. 2004 Jun;24(12):5340-52
10579910 - Exp Cell Res. 1999 Nov 25;253(1):47-54
7529876 - Mol Cell Biol. 1995 Feb;15(2):954-63
12826400 - Trends Biochem Sci. 2003 Jun;28(6):284-93
12932330 - Curr Biol. 2003 Aug 19;13(16):1442-50
9666002 - J Clin Microbiol. 1998 Aug;36(8):2258-63
11722731 - Mol Microbiol. 2001 Nov;42(3):631-44
11788577 - J Biol Chem. 2002 Mar 1;277(9):6775-8
10588744 - Proc Natl Acad Sci U S A. 1999 Dec 7;96(25):14559-64
11359909 - Mol Cell Biol. 2001 Jun;21(12):4016-31
12231355 - Curr Opin Cell Biol. 2002 Oct;14(5):594-602
10082587 - Mol Cell Biol. 1999 Apr;19(4):3205-15
12640026 - J Cell Sci. 2003 Apr 15;116(Pt 8):1409-16
11988069 - Biochem J. 2002 Aug 1;365(Pt 3):591-603
1709258 - Nature. 1991 May 2;351(6321):69-72
9694867 - J Biol Chem. 1998 Aug 14;273(33):21125-31
7743510 - Cancer Res. 1995 May 15;55(10):2111-5
9609753 - Gastroenterology. 1998 Jun;114(6):1169-79
11743164 - Science. 2002 Jan 25;295(5555):683-6
7615549 - J Biol Chem. 1995 Jul 21;270(29):17437-41
8941336 - Biochem Biophys Res Commun. 1996 Nov 21;228(3):662-8
12419219 - Mol Cell. 2002 Oct;10(4):745-55
14665621 - J Biol Chem. 2004 Feb 27;279(9):8497-505
7509446 - Mol Cell Biol. 1994 Mar;14(3):1680-8
12391297 - Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14428-33
7935386 - Mol Cell Biol. 1994 Oct;14(10):6674-82
15246681 - Biochim Biophys Acta. 2004 Jul 5;1692(2-3):77-102
9582366 - J Biol Chem. 1998 May 22;273(21):13223-9
2586553 - N Engl J Med. 1989 Dec 7;321(23):1562-6
12446738 - J Biol Chem. 2003 Feb 7;278(6):3664-70
8007082 - JAMA. 1994 Jul 6;272(1):65-9
10684851 - J Exp Med. 2000 Feb 21;191(4):593-602
10375095 - Cancer. 1999 Jun 15;85(12):2506-11
15132773 - Cancer Sci. 2004 May;95(5):442-7
11929545 - Mol Microbiol. 2002 Feb;43(4):971-80
10383517 - Aliment Pharmacol Ther. 1999 Jul;13(7):851-6
12422220 - Nature. 2002 Nov 7;420(6911):89-93
7566154 - Nature. 1995 Oct 12;377(6549):539-44
10655519 - Proc Natl Acad Sci U S A. 2000 Feb 1;97(3):1263-8
10722135 - Epidemiol Infect. 2000 Feb;124(1):91-6
12775840 - Science. 2003 May 30;300(5624):1430-4
11207572 - Cell Microbiol. 2000 Apr;2(2):155-64
15343275 - Nat Rev Cancer. 2004 Sep;4(9):688-94
1722201 - J Biol Chem. 1991 Dec 25;266(36):24249-52
9135515 - Gut. 1997 Mar;40(3):297-301
12554652 - EMBO J. 2003 Feb 3;22(3):515-28
11807823 - J Cell Physiol. 2002 Feb;190(2):189-99
References_xml – ident: R26
  doi: 10.1038/nature01082
– ident: R10
  doi: 10.1016/S0960-9822(03)00544-X
– ident: R30
  doi: 10.1038/351069a0
– ident: R1
  doi: 10.1074/jbc.M210670200
– volume: 228
  start-page: 662
  year: 1996
  ident: R9
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1006/bbrc.1996.1714
– ident: R25
  doi: 10.1128/MCB.24.12.5340-5352.2004
– ident: R5
  doi: 10.1046/j.1462-5822.2000.00043.x
– ident: R27
  doi: 10.1128/MCB.21.12.4016-4031.2001
– ident: R21
  doi: 10.1126/science.1067147
– ident: R3
  doi: 10.1084/jem.191.4.593
– ident: R20
  doi: 10.1073/pnas.222375399
– ident: R48
  doi: 10.1046/j.1365-2958.2002.02781.x
– ident: R53
  doi: 10.1002/jcp.10054
– ident: R19
  doi: 10.1074/jbc.M309964200
– ident: R12
  doi: 10.1073/pnas.90.12.5791
– ident: R39
  doi: 10.1242/jcs.00373
– ident: R36
  doi: 10.1016/S0021-9258(18)54220-4
– ident: R56
  doi: 10.1083/jcb.200312013
– ident: R35
  doi: 10.1128/MCB.19.4.3205
– ident: R29
  doi: 10.1016/S1097-2765(02)00681-0
– ident: R14
  doi: 10.1046/j.1365-2036.1999.00546.x
– ident: R49
  doi: 10.1073/pnas.97.3.1263
– ident: R37
  doi: 10.1016/S0021-9258(19)30019-5
– volume: 273
  start-page: 13223
  year: 1998
  ident: R50
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.273.21.13223
– ident: R8
  doi: 10.1128/MCB.15.2.954
– ident: R42
  doi: 10.1002/(SICI)1097-0142(19990615)85:12<2506::AID-CNCR3>3.0.CO;2-I
– ident: R43
  doi: 10.1128/MCB.14.3.1680
– ident: R44
  doi: 10.1016/j.bbamcr.2004.04.008
– volume: 55
  start-page: 2111
  year: 1995
  ident: R7
  publication-title: Cancer Res.
– ident: R11
  doi: 10.1083/jcb.200208039
– ident: R52
  doi: 10.1056/NEJMoa001999
– ident: R28
  doi: 10.1128/MCB.19.4.3125
– ident: R18
  doi: 10.1038/nrc1433
– ident: R23
  doi: 10.1016/S0016-5085(98)70422-6
– volume: 14
  start-page: 6674
  year: 1994
  ident: R33
  publication-title: Mol. Cell. Biol.
– volume: 95
  start-page: 442
  year: 2004
  ident: R22
  publication-title: Cancer Sci.
  doi: 10.1111/j.1349-7006.2004.tb03229.x
– ident: R15
  doi: 10.1056/NEJM198912073212302
– ident: R46
  doi: 10.1074/jbc.C100754200
– ident: R45
  doi: 10.1073/pnas.96.25.14559
– volume: 22
  start-page: 515
  year: 2003
  ident: R47
  publication-title: EMBO J.
  doi: 10.1093/emboj/cdg050
– ident: R34
  doi: 10.1126/science.287.5457.1497
– ident: R51
  doi: 10.1074/jbc.M208155200
– volume: 365
  start-page: 591
  year: 2002
  ident: R17
  publication-title: Biochem. J.
  doi: 10.1042/bj20020065
– ident: R57
  doi: 10.1074/jbc.273.33.21125
– volume: 28
  start-page: 284
  year: 2003
  ident: R31
  publication-title: Sci.
– ident: R13
  doi: 10.1016/S0955-0674(02)00368-X
– ident: R54
  doi: 10.1128/JCM.36.8.2258-2263.1998
– ident: R32
  doi: 10.1001/jama.1994.03520010077036
– ident: R4
  doi: 10.1046/j.1365-2958.2001.02649.x
– ident: R24
  doi: 10.1038/377539a0
– ident: R58
  doi: 10.1016/S1097-2765(04)00050-4
– ident: R6
  doi: 10.1074/jbc.270.29.17437
– ident: R41
  doi: 10.1074/jbc.M312575200
– ident: R55
  doi: 10.1017/S0950268899003209
– ident: R38
  doi: 10.1136/gut.40.3.297
– ident: R2
  doi: 10.1126/science.1081919
– volume: 11
  start-page: 1955
  year: 1995
  ident: R40
  publication-title: Oncogene
– ident: R16
  doi: 10.1006/excr.1999.4668
– reference: 12826400 - Trends Biochem Sci. 2003 Jun;28(6):284-93
– reference: 7566154 - Nature. 1995 Oct 12;377(6549):539-44
– reference: 10688800 - Science. 2000 Feb 25;287(5457):1497-500
– reference: 9609753 - Gastroenterology. 1998 Jun;114(6):1169-79
– reference: 11359909 - Mol Cell Biol. 2001 Jun;21(12):4016-31
– reference: 15169898 - Mol Cell Biol. 2004 Jun;24(12):5340-52
– reference: 11807823 - J Cell Physiol. 2002 Feb;190(2):189-99
– reference: 10722135 - Epidemiol Infect. 2000 Feb;124(1):91-6
– reference: 11743164 - Science. 2002 Jan 25;295(5555):683-6
– reference: 7529876 - Mol Cell Biol. 1995 Feb;15(2):954-63
– reference: 10655519 - Proc Natl Acad Sci U S A. 2000 Feb 1;97(3):1263-8
– reference: 12640026 - J Cell Sci. 2003 Apr 15;116(Pt 8):1409-16
– reference: 12391297 - Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14428-33
– reference: 14967142 - Mol Cell. 2004 Feb 13;13(3):341-55
– reference: 15343275 - Nat Rev Cancer. 2004 Sep;4(9):688-94
– reference: 12932330 - Curr Biol. 2003 Aug 19;13(16):1442-50
– reference: 14665621 - J Biol Chem. 2004 Feb 27;279(9):8497-505
– reference: 12554652 - EMBO J. 2003 Feb 3;22(3):515-28
– reference: 12775840 - Science. 2003 May 30;300(5624):1430-4
– reference: 10684851 - J Exp Med. 2000 Feb 21;191(4):593-602
– reference: 12419219 - Mol Cell. 2002 Oct;10(4):745-55
– reference: 10383517 - Aliment Pharmacol Ther. 1999 Jul;13(7):851-6
– reference: 10375095 - Cancer. 1999 Jun 15;85(12):2506-11
– reference: 10579910 - Exp Cell Res. 1999 Nov 25;253(1):47-54
– reference: 11722731 - Mol Microbiol. 2001 Nov;42(3):631-44
– reference: 9694867 - J Biol Chem. 1998 Aug 14;273(33):21125-31
– reference: 11988069 - Biochem J. 2002 Aug 1;365(Pt 3):591-603
– reference: 15132773 - Cancer Sci. 2004 May;95(5):442-7
– reference: 12719469 - J Cell Biol. 2003 Apr 28;161(2):249-55
– reference: 12582165 - J Biol Chem. 2003 Apr 18;278(16):13952-8
– reference: 8941336 - Biochem Biophys Res Commun. 1996 Nov 21;228(3):662-8
– reference: 1709258 - Nature. 1991 May 2;351(6321):69-72
– reference: 15246681 - Biochim Biophys Acta. 2004 Jul 5;1692(2-3):77-102
– reference: 8007082 - JAMA. 1994 Jul 6;272(1):65-9
– reference: 11929545 - Mol Microbiol. 2002 Feb;43(4):971-80
– reference: 10082579 - Mol Cell Biol. 1999 Apr;19(4):3125-35
– reference: 7615549 - J Biol Chem. 1995 Jul 21;270(29):17437-41
– reference: 11556297 - N Engl J Med. 2001 Sep 13;345(11):784-9
– reference: 12422220 - Nature. 2002 Nov 7;420(6911):89-93
– reference: 11788577 - J Biol Chem. 2002 Mar 1;277(9):6775-8
– reference: 2480346 - J Biol Chem. 1989 Dec 15;264(35):20886-93
– reference: 10588744 - Proc Natl Acad Sci U S A. 1999 Dec 7;96(25):14559-64
– reference: 7935386 - Mol Cell Biol. 1994 Oct;14(10):6674-82
– reference: 9135515 - Gut. 1997 Mar;40(3):297-301
– reference: 12231355 - Curr Opin Cell Biol. 2002 Oct;14(5):594-602
– reference: 8516329 - Proc Natl Acad Sci U S A. 1993 Jun 15;90(12):5791-5
– reference: 9582366 - J Biol Chem. 1998 May 22;273(21):13223-9
– reference: 10082587 - Mol Cell Biol. 1999 Apr;19(4):3205-15
– reference: 14963045 - J Biol Chem. 2004 Apr 23;279(17):17205-16
– reference: 7478513 - Oncogene. 1995 Nov 16;11(10):1955-62
– reference: 7509446 - Mol Cell Biol. 1994 Mar;14(3):1680-8
– reference: 9666002 - J Clin Microbiol. 1998 Aug;36(8):2258-63
– reference: 1722201 - J Biol Chem. 1991 Dec 25;266(36):24249-52
– reference: 7743510 - Cancer Res. 1995 May 15;55(10):2111-5
– reference: 11207572 - Cell Microbiol. 2000 Apr;2(2):155-64
– reference: 15263022 - J Cell Biol. 2004 Jul 19;166(2):283-95
– reference: 12446738 - J Biol Chem. 2003 Feb 7;278(6):3664-70
– reference: 2586553 - N Engl J Med. 1989 Dec 7;321(23):1562-6
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Snippet Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley...
Infection with cagA-positive Helicobacter pylori (H. pylori) is associated with atrophic gastritis, peptic ulcer, and gastric adenocarcinoma. The cagA gene...
Infection with cagA -positive Helicobacter pylori ( H. pylori ) is associated with atrophic gastritis, peptic ulcer, and gastric adenocarcinoma. The cagA gene...
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StartPage 261
SubjectTerms Antigens, Bacterial - metabolism
Bacterial Proteins - metabolism
Cell Membrane - enzymology
Cells, Cultured
Focal Adhesion Protein-Tyrosine Kinases - analysis
Focal Adhesion Protein-Tyrosine Kinases - antagonists & inhibitors
Focal Adhesion Protein-Tyrosine Kinases - metabolism
Gastric Mucosa - enzymology
Gastric Mucosa - microbiology
Gastric Mucosa - pathology
Helicobacter Infections - enzymology
Helicobacter pylori
Helicobacter pylori - pathogenicity
Humans
Intracellular Signaling Peptides and Proteins - metabolism
Phenotype
Phosphorylation
Phosphotransferases - metabolism
Protein Interaction Mapping
Protein Tyrosine Phosphatase, Non-Receptor Type 11
Protein Tyrosine Phosphatases - metabolism
Protein-Tyrosine Kinases
Proto-Oncogene Proteins - metabolism
src-Family Kinases
Title Focal Adhesion Kinase Is a Substrate and Downstream Effector of SHP-2 Complexed with Helicobacter pylori CagA
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