The blood compatibility challenge. Part 2: Protein adsorption phenomena governing blood reactivity

• Published in: Acta biomaterialia Vol. 94; pp. 11 - 24
• Main Authors: Brash, John L., Horbett, Thomas A., Latour, Robert A., Tengvall, Pentti
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.08.2019; Elsevier BV
• Subjects: Adsorption; Animals; Annan materialteknik; Antifouling; Biocompatibility; Biocompatible Materials; Biomaterials; Biomaterials Science; Biomaterialvetenskap; Biomedical materials; Blood; Blood Coagulation; Blood compatibility; Blood Platelets - metabolism; Blood Proteins - chemistry; Coagulation; Complement Activation; Composition effects; Denaturation; Fibrinogen - metabolism; Humans; Materials Testing; Medical devices; Medical electronics; Medical equipment; Other Materials Engineering; Platelet Adhesiveness; Protein adsorption; Protein Binding; Protein composition; Protein Conformation; Protein denaturation; Proteins; Surface; Surface Properties; Thrombosis; Thrombosis - metabolism; Thrombosis - prevention & control; Blood coagulation; Blood compatibility; Complement activation; Antifouling; Protein adsorption; Thrombosis; Surface

[Display omitted] The adsorption of proteins is the initiating event in the processes occurring when blood contacts a “foreign” surface in a medical device, leading inevitably to thrombus formation. Knowledge of protein adsorption in this context has accumulated over many years but remains fragmenta...