Urine biomarkers individually and as a consensus model show high sensitivity and specificity for detecting UTIs

• Published in: BMC infectious diseases Vol. 24; no. 1; pp. 153 - 11
• Main Authors: Akhlaghpour, Marzieh, Haley, Emery, Parnell, Laura, Luke, Natalie, Mathur, Mohit, Festa, Richard A., Percaccio, Michael, Magallon, Jesus, Remedios-Chan, Mariana, Rosas, Alain, Wang, Jimin, Jiang, Yan, Anderson, Lori, Baunoch, David
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 31.01.2024; BioMed Central; BMC
• Subjects: Antibiotics; Asymptomatic; Bacteriuria; Biological markers; Biomarkers; Care and treatment; Density; Diagnosis; Diagnostic testing; E coli; Enzyme-linked immunosorbent assay; Flora; Gelatinase; Health aspects; Identification and classification; IL-1β; Interleukin 1β (IL-1β); Interleukin 8; Interleukin 8 (IL-8); Leukocytes (neutrophilic); Likelihood ratio; Lipocalin; Medical research; Medicine, Experimental; Microorganisms; Neutrophil gelatinase-associated lipocalin (NGAL); Neutrophils; Pathogens; Polymerase chain reaction; Questionnaires; Sensitivity; Urinary biomarkers; Urinary tract; Urinary tract infection (UTI); Urinary tract infections; Urine; Urogenital system; Urology; United States; Diagnostic testing; Interleukin 8 (IL-8); Urinary biomarkers; Neutrophil gelatinase-associated lipocalin (NGAL); Urinary tract infection (UTI); Interleukin 1β (IL-1β)

Current diagnoses of urinary tract infection (UTI) by standard urine culture (SUC) has significant limitations in sensitivity, especially for fastidious organisms, and the ability to identify organisms in polymicrobial infections. The significant rate of both SUC "negative" or "mixed...