Ethanol and its Nonoxidative Metabolites Promote Acute Liver Injury by Inducing ER Stress, Adipocyte Death, and Lipolysis - Park, Seol Hee; Seo, Wonhyo; Xu, Ming-Jiang; Mackowiak, Bryan; Lin, Yuhong; He, Yong; Fu, Yaojie; Hwang, Seonghwan; Kim, Seung-Jin; Guan, Yukun; Feng, Dechun; Yu, Liqing; et al. (Cellular and molecular gastroenterology and hepatology, 2023)
Keywords: Acetaldehyde - metabolism; ADH; Adipocytes - metabolism; ALDH; Animals; Binge; Carboxylesterase 1d; Chemical and Drug Induced Liver Injury; Endoplasmic Reticulum Stress; Esters - metabolism; Ethanol - toxicity; FAEE; Fatty Acids - metabolism; Gastroenterology and Hepatology; Lipolysis; Liver - metabolism; Mice; Original Research; FFA; ADH; GTT; JNK; TUDCA; HFD; ITT; ALT; mRNA; CLS; PERK; PBA; TUNEL; ALDH2; Binge; CHOP; cDNA; Carboxylesterase 1d; RT-qPCR; WT; HSL; AST; KO; PKA; ER; eIF2α; ALDH; TG; IRE1α; ALD; PI; FAEE; CYP2E1; crown-like structure; alanine aminotransferase; insulin tolerance test; –; tauroursodeoxycholic acid; —; c-Jun N-terminal kinase; fatty acid ethyl ester; reverse-transcription quantitative polymerase chain reaction; high-fat diet; hormone-sensitive lipase; triglyceride; glucose tolerance test; 4-phenylbutyric acid; alcohol-associated liver disease; aldehyde dehydrogenase 2; alcohol dehydrogenase; terminal deoxynucleotidyl transferase–mediated deoxyuridine triphosphate nick-end labeling; complementary DNA; messenger RNA; propidium iodide; protein kinase A; knockout; cytochrome p450 2E1; aspartate aminotransferase; free fatty acid; wild-type; endoplasmic reticulum