Association of TLR4 and TLR9 gene polymorphisms with cervical HR-HPV infection status in Chinese Han population

• Published in: BMC infectious diseases Vol. 23; no. 1; pp. 152 - 11
• Main Authors: Zhang, Chunlin, Yang, Zhiping, Luo, Ping, Li, Ting, Wang, Sutong, Sun, Fenglan, Gong, Ping, Mei, Bing
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 13.03.2023; BioMed Central; BMC
• Subjects: Analysis; Case-Control Studies; Complications and side effects; East Asian People; Enzymes; Female; Gene polymorphism; Genes; Genetic aspects; Genetic polymorphisms; Genetic Predisposition to Disease; Genetic research; Genotype; Genotype & phenotype; Genotypes; Health aspects; Human papillomavirus; Humans; Infection; Infections; Infectious diseases; Medical research; Medicine, Experimental; Multiple HR-HPV infections; Mutants; Papillomavirus infections; Papillomavirus Infections - genetics; Persistent HR-HPV infection; Persistent infection; Polymerase chain reaction; Polymorphism; Polymorphism, Single Nucleotide; Prevention; Proteins; Rank tests; Real-Time Polymerase Chain Reaction; Regression analysis; Restriction fragment length polymorphism; Retrospective Studies; Sexually transmitted diseases; Single nucleotide polymorphisms; Software; TLR4 protein; TLR9 protein; Toll-Like Receptor 4 - genetics; Toll-Like Receptor 9 - genetics; Toll-like receptors; Womens health; China; Toll-like receptors; Persistent HR-HPV infection; Single nucleotide polymorphisms; Multiple HR-HPV infections
• ISSN: 1471-2334; 1471-2334
• DOI: 10.1186/s12879-023-08116-z

Toll-like receptors (TLRs) may be involved in the natural history of human papillomavirus (HPV) infection. In our study, we aimed to investigate the association of TLR4 (rs10116253, rs1927911, rs10759931) and TLR9 (rs187084, rs352140) gene polymorphisms with cervical persistent high-risk HPV (HR-HPV...