Therapeutic vaccine BRII-179 restores HBV-specific immune responses in patients with chronic HBV in a phase Ib/IIa study

• Published in: JHEP reports Vol. 3; no. 6; p. 100361
• Main Authors: Ma, Haiyan, Lim, Tien Huey, Leerapun, Apinya, Weltman, Martin, Jia, Jidong, Lim, Young-suk, Tangkijvanich, Pisit, Sukeepaisarnjaroen, Wattana, Ji, Yun, Le Bert, Nina, Li, Dong, Zhang, Yao, Hamatake, Robert, Tan, Nicole, Li, Chunming, Strasser, Simone I., Ding, Huiguo, Yoon, Jung-Hwan, Stace, Nigel H., Ahmed, Tanvir, Anderson, Dave E., Yan, Li, Bertoletti, Antonio, Zhu, Qing, Yuen, Man-Fung
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.12.2021; Elsevier
• Subjects: BRII-179; CHB; Gastroenterology and Hepatology; HBV-specific immune response; IFN-alpha; immunotherapy; AE; IM; Anti-HBs; HBeAg; PEG-IFN-α; ALT; HBsAg; IU; IFN-alpha; PBMCs; BRII-179; ELISpot; HBV-specific immune response; IFN-α; NA; SAE; immunotherapy; CHB; Th1; HBV; BMI; interferon-α; hepatitis B virus; alanine aminotransferase; intramuscular; hepatitis B e antigen; pegylated interferon-α; chronic hepatitis B; peripheral blood mononuclear cells; serious adverse events; international units; nucleos(t)ide analogue; hepatitis B surface antigen; body mass index; adverse event; hepatitis B surface antibody; T helper type 1; enzyme-linked immune absorbent spot; ALT, alanine aminotransferase; HBV, hepatitis B virus; HBeAg, hepatitis B e antigen; CHB, chronic hepatitis B; NA, nucleos(t)ide analogue; HBsAg, hepatitis B surface antigen; Th1, T helper type 1; BMI, body mass index; IM, intramuscular; IU, international units; AE, adverse event; IFN-α, interferon-α; Anti-HBs, hepatitis B surface antibody; ELISpot, enzyme-linked immune absorbent spot; PEG-IFN-α, pegylated interferon-α; SAE, serious adverse events; PBMCs, peripheral blood mononuclear cells

Functional cure of chronic HBV infection (CHB) without life-long treatment requires the restoration of defective HBV-specific humoral and cellular immunity. Therapeutic vaccines based on the major structural and non-structural proteins have been tested in patients with CHB but have shown scarce immu...