The Long Noncoding RNAs NEAT1 and MALAT1 Bind Active Chromatin Sites

• Published in: Molecular cell Vol. 55; no. 5; pp. 791 - 802
• Main Authors: West, Jason A., Davis, Christopher P., Sunwoo, Hongjae, Simon, Matthew D., Sadreyev, Ruslan I., Wang, Peggy I., Tolstorukov, Michael Y., Kingston, Robert E.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 04.09.2014
• Subjects: Binding Sites; chromatin; Chromatin - metabolism; DNA; genes; Humans; loci; Models, Genetic; non-coding RNA; Nucleic Acid Hybridization; nucleotide sequences; RNA, Long Noncoding - analysis; RNA, Long Noncoding - chemistry; RNA, Long Noncoding - metabolism; transcription (genetics); Transcription, Genetic

Mechanistic roles for many lncRNAs are poorly understood, in part because their direct interactions with genomic loci and proteins are difficult to assess. Using a method to purify endogenous RNAs and their associated factors, we mapped the genomic binding sites for two highly expressed human lncRNA...