miR-122 promotes hepatic lipogenesis via inhibiting the LKB1/AMPK pathway by targeting Sirt1 in non-alcoholic fatty liver disease

• Published in: Molecular medicine (Cambridge, Mass.) Vol. 25; no. 1; pp. 26 - 13
• Main Authors: Long, Jun-Ke, Dai, Wen, Zheng, Ya-Wen, Zhao, Shui-Ping
• Format: Journal Article
• Language: English
• Published: England BioMed Central 13.06.2019; BMC
• Subjects: AMPK pathway; Binding sites; Biomarkers; Fatty acids; Fatty liver; Homeostasis; Laboratory animals; Lipids; Lipogenesis; Liver diseases; Metabolism; MicroRNAs; miR-122; Non-alcoholic fatty liver disease; Pathogenesis; Plasmids; Proteins; Sirt1; United States > US; China; Germany; Sirt1; AMPK pathway; Lipogenesis; Non-alcoholic fatty liver disease; miR-122

Non-alcoholic fatty liver disease (NAFLD) is a common hepatic disease with an increasing prevalence but an unclear aetiology. This study aimed to investigate the functional implications of microRNA-122 (miR-122) in the pathogenesis of NAFLD and the possible molecular mechanisms. Both in vitro and in...