Macrophages in obesity and non-alcoholic fatty liver disease: Crosstalk with metabolism

• Published in: JHEP reports Vol. 1; no. 1; pp. 30 - 43
• Main Authors: Lefere, Sander, Tacke, Frank
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.05.2019; Elsevier
• Subjects: Gastroenterology and Hepatology; immunometabolism; innate immunity; liver immunology; NASH; Review; steatohepatitis, Kupffer cells; liver immunology; innate immunity; NASH; immunometabolism; steatohepatitis, Kupffer cells

Non-alcoholic fatty liver disease (NAFLD) is the most prevalent liver disease worldwide, and a major cause of liver cirrhosis and hepatocellular carcinoma. NAFLD is intimately linked with other metabolic disorders characterized by insulin resistance. Metabolic diseases are driven by chronic inflamma...