Network evolution: rewiring and signatures of conservation in signaling

• Published in: PLoS computational biology Vol. 8; no. 3; p. e1002411
• Main Authors: Sun, Mark G F, Sikora, Martin, Costanzo, Michael, Boone, Charles, Kim, Philip M
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.03.2012; Public Library of Science (PLoS)
• Subjects: Biology; Comparative analysis; Computational biology; Computer Simulation; Conserved Sequence - genetics; Evolution, Molecular; Fungal Proteins - genetics; Fungi - genetics; Genetics; Homology (Biology); Kinases; Models, Genetic; Peptides; Phosphotransferases; Phylogenetics; Physiological aspects; Protein binding; Proteins; Signal transduction; Signal Transduction - genetics; src Homology Domains - genetics; Studies; Yeast; Canada; Fungi; Signal Transduction; Computer Simulation; Conserved Sequence; Fungal Proteins; Models, Genetic; Evolution, Molecular; src Homology Domains

The analysis of network evolution has been hampered by limited availability of protein interaction data for different organisms. In this study, we investigate evolutionary mechanisms in Src Homology 3 (SH3) domain and kinase interaction networks using high-resolution specificity profiles. We constru...